5598-38-9Relevant articles and documents
Synthesis of phosphatidylcholine having a very long chain polyunsaturated fatty acid
Haider, Syed Shabbir,Tanaka, Masatoshi,Alam, Md Khorshed,Nakajima, Shuhei,Baba, Naomichi,Shimizu, Sakayu
, p. 175 - 176 (2007/10/03)
A phosphatidylcholine 9 bearing icosadienoyl and docosahexaenoyl groups at the 1-and 2-positions respectively was synthesized. The synthetic route involves carbon chain elongation of linoleic acid via malonic ester synthesis, preparation of lyso-phosphatidylcholine via lipase-catalyzed mono-acylation of 2-O-methoxyethoxymethylglycerol and phosphodiester synthesis, and finally DCC-mediated esterification.