56077-78-2Relevant articles and documents
Synthesis method and application of two sulfonyl pyrrolidine P-CABs
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, (2020/09/16)
The invention discloses a synthesis method and application of two sulfonyl pyrrolidine P-CABs. The general structural formula (I) of the sulfonyl pyrrolidine is shown in the specification. The sulfonyl pyrrolidine has excellent gastric acid secretion inhibition effect. The synthesis method has the advantages of fewer process steps and easy availability of raw materials, and is suitable for industrial production.
1-arylsulfonyl-2-(Pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs
Shin, Jai Moo,Sachs, George,Cho, Young-Moon,Garst, Michael
experimental part, p. 5247 - 5280 (2010/03/30)
New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
Process for preparing isomerically pure prodrugs of proton pump inhibitors
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Page/Page column 13, (2010/02/10)
Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description.