5621-69-2

Basic information

• Product Name: 3-CHLORO-2'-METHYLBENZOPHENONE
• Synonyms: 3-CHLORO-2'-METHYLBENZOPHENONE
• CAS NO: 5621-69-2
• Molecular Formula: C₁₄H₁₁ClO
• Molecular Weight: 230.7
• Mol File: 5621-69-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 330.3°C at 760 mmHg
• Flash Point: 184.7°C
• Appearance: /
• Density: 1.178g/cm³
• Vapor Pressure: 0.000168mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 3-CHLORO-2'-METHYLBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2'-METHYLBENZOPHENONE(5621-69-2)
• EPA Substance Registry System: 3-CHLORO-2'-METHYLBENZOPHENONE(5621-69-2)

Safety Data

• Hazardous Substances Data: 5621-69-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H11ClO/c1-10-5-2-3-8-13(10)14(16)11-6-4-7-12(15)9-11/h2-9H,1H3

Upstream product

• 201230-82-2 carbon monoxide 
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• 108-88-3 toluene 
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Downstream Products

• 1027313-84-3 3-(3-chloro-phenyl)-3-o-tolyl-oxirane-2-carboxylic acid 

Relevant articles and documents

Photoenolization/nucleophilic addition enables direct access to 3-alkyl-3-hydroxy-indolin-2-ones

A light-driven, catalyst- and additive-free photoenolization/nucleophilic addition reaction for the synthesis of 3-benzyl-3-hydroxyindolin-2-ones is presented. In this reaction, 2-methylbenzophenones undergo light-induced enolization process to afford hydroxy-o-quinodimethanes (hydroxy-o-QDMs), which are then immediately captured by the electrophilic isatins. The reaction utilizes green and clean light energy to realize the C–H activation of the inert benzyl position of 2-methylbenzophenones. This method tolerates a wide scope of substrates and provides concise access to a series of novel 3-benzyl-3-hydroxyindolin-2-ones with 60–99% yields.

Palladium-phosphinous acid-catalyzed cross-coupling of aryl and acyl halides with aryl-, alkyl-, and vinylzinc reagents

(Chemical Equation Presented) Several palladium-phosphinous acids have been prepared and employed in cross-coupling reactions of aryl or acyl halides with aliphatic and aromatic organozinc reagents. The POPd7-catalyzed reaction of aryl halides, including electron-rich aryl chlorides, and arylzinc reagents was found to afford biaryls exhibiting alkoxy, alkylthio, amino, ketone, cyano, nitro, ester, and heteroaryl groups in 75-93% yield. Excellent results were obtained with sterically hindered substrates which gave di- and tri-ortho-substituted biaryls in up to 92% yield. Aryl halides also undergo POPd7-catalyzed aryl-vinyl and aryl-alkyl bond formation under mild conditions. Styrenes and alkylarenes were prepared in 79-93% yield from aryl halides and vinyl or alkylzinc reagents. The replacement of aryl halides by acyl halides provides access to ketones which were produced in up to 98% yield when POPd was used as catalyst. This approach overcomes the limited substrate scope, reduced regiocontrol, and low functional group tolerance of traditional Friedel-Crafts acylation methods.