5626-64-2Relevant articles and documents
Efficient preparation of proline N-carboxyanhydride using polymer-supported bases
Gulin, Oscar P.,Rabanal, Francesc,Giralt, Ernest
, p. 5385 - 5388 (2007/10/03)
A procedure for the preparation of proline N-carboxyanhydride in high yield and purity is described using polymer-supported tertiary amines. The polymer-supported amine can be recycled with a basic wash and filtration of the resin. The procedure facilitates the access to the efficient preparation of the polyproline polymer with potential therapeutic interest.