56460-32-3Relevant articles and documents
In vivo targeted delivery of nucleic acids and CRISPR genome editors enabled by GSH-responsive silica nanoparticles
Wang, Yuyuan,Shahi, Pawan K.,Wang, Xiuxiu,Xie, Ruosen,Zhao, Yi,Wu, Min,Roge, Seth,Pattnaik, Bikash R.,Gong, Shaoqin
, p. 296 - 309 (2021)
The rapid development of gene therapy and genome editing techniques brings up an urgent need to develop safe and efficient nanoplatforms for nucleic acids and CRISPR genome editors. Herein we report a stimulus-responsive silica nanoparticle (SNP) capable of encapsulating biomacromolecules in their active forms with a high loading content and loading efficiency as well as a well-controlled nanoparticle size (~50 nm). A disulfide crosslinker was integrated into the silica network, endowing SNP with glutathione (GSH)-responsive cargo release capability when internalized by target cells. An imidazole-containing component was incorporated into the SNP to enhance the endosomal escape capability. The SNP can deliver various cargos, including nucleic acids (e.g., DNA and mRNA) and CRISPR genome editors (e.g., Cas9/sgRNA ribonucleoprotein (RNP), and RNP with donor DNA) with excellent efficiency and biocompatibility. The SNP surface can be PEGylated and functionalized with different targeting ligands. In vivo studies showed that subretinally injected SNP conjugated with all-trans-retinoic acid (ATRA) and intravenously injected SNP conjugated with GalNAc can effectively deliver mRNA and RNP to murine retinal pigment epithelium (RPE) cells and liver cells, respectively, leading to efficient genome editing. Overall, the SNP is a promising nanoplatform for various applications including gene therapy and genome editing.
Thermotropic liquid crystals of 1H-imidazole amphiphiles showing hexagonal columnar and micellar cubic phases
Seo, Sang Hyuk,Park, Jun Ha,Tew, Gregory N.,Chang, Ji Young
, p. 6839 - 6844 (2007)
The linear and polycatenar type 1H-imidazole amphiphiles showing a strong self-assembly tendency to build various supramolecular structures in bulk were synthesized by the esterification reaction of 4′-alkyloxy phenols (for 1-4) and hydroxyphenyl trialkyl
An Imidazole-Functionalized Phosphatidylcholine Derivative: Nucleophilic Vesicles with Adjustable Reactivity
Moss, Robert A.,Scrimin, Paolo,Bhattacharya, Santanu,Swarup, Shanti
, p. 6209 - 6210 (1987)
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N-indolyl imidazole formamide compound and preparation method and application thereof
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Paragraph 0050-0051, (2021/06/09)
The invention belongs to the field of medicines, and relates to an N-indolyl imidazole formamide compound and a preparation method and application thereof. The structural general formula of the compound is shown in the specification. A pharmaceutical composition comprises the N-indolyl imidazole carboxamide compound, pharmaceutically acceptable salt, hydrate or solvate of the N-indolyl imidazole carboxamide compound and a pharmaceutically acceptable carrier of the N-indolyl imidazole carboxamide compound. The invention also discloses the application of the N-indolyl imidazole formamide compound or the pharmaceutically acceptable salt, hydrate or solvate thereof or the pharmaceutical composition in the preparation of anti-hyperuricemia and anti-gout drugs. Tests prove that the compound shows a good effect in an in-vitro xanthine oxidase inhibitory activity test. The preparation method is simple and feasible, relatively high in yield and easy for large-scale production.
UNIVERSAL MULTI-FUNCTIONAL GSH-RESPONSIVE SILICA NANOPARTICLES FOR DELIVERY OF BIOMOLECULES INTO CELLS
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Paragraph 0102, (2021/11/26)
The present technology provides a nanoparticle comprising: a silica network comprising crosslinked polysiloxanes, wherein the crosslinks between polysiloxanes comprise disulfide linkages, the polysiloxanes optionally bear weakly basic functional groups, the nanoparticle comprises an exterior surface comprising surface-modifying groups attached to and surrounding the silica network, wherein the surface-modifying groups comprising polyethylene glycol (PEG), polysarcosine, polyzwitterion or combinations of two or more of thereof; and the nanoparticle has an average diameter of 15 nm to 500 nm. The nanoparticles herein may include biomolecules such as polynucleic acids, proteins, and complexes thereof, e.g, Cas9 RNP.