56501-52-1

Basic information

• Product Name: 5,6,11-trimethyl-6H-pyrido[4,3-b]carbazol-9-ol
• Synonyms: 5,6,11-Trimethyl-6H-pyrido(4,3-b)carbazol-9-ol; 6H-Pyrido(4,3-b)carbazol-9-ol, 5,6,11-trimethyl-
• CAS NO: 56501-52-1
• Molecular Formula: C₁₈H₁₆N₂O
• Molecular Weight: 276.3324
• Mol File: 56501-52-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 536.2°C at 760 mmHg
• Flash Point: 278.1°C
• Density: 1.26g/cm³
• Vapor Pressure: 4.1E-12mmHg at 25°C
• Refractive Index: 1.68
• CAS DataBase Reference: 5,6,11-trimethyl-6H-pyrido[4,3-b]carbazol-9-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,11-trimethyl-6H-pyrido[4,3-b]carbazol-9-ol(56501-52-1)
• EPA Substance Registry System: 5,6,11-trimethyl-6H-pyrido[4,3-b]carbazol-9-ol(56501-52-1)

Safety Data

• Hazardous Substances Data: 56501-52-1(Hazardous Substances Data)

Upstream product

• 111674-76-1 9-formyl-5,6,11-trimethyl-6H-pyrido<4,3-b>carbazole 
• 18073-33-1 6-methylellipticine 
• 18073-32-0 9-Methoxy-5,6,11-trimethyl-6H-pyrido<4,3-b>carbazol 
• 18073-18-2 1,4,9-trimethyl-9H-carbazole-3-carbaldehyde 
• 1618136-61-0 C₂₈H₃₃N₃O₆S 
• 14501-66-7 1,4-dimethylcarbazole-3-carboxaldehyde 
• 18073-26-2 3-(2,2-diethoxyethyliminomethyl)-1,4,9-trimethylcarbazole 
• 1326776-30-0 3-(2,2-diethoxyethylaminomethyl)-1,4,9-trimethylcarbazole 
• 10371-86-5 9-methoxyellipticine 

Downstream Products

• 1618136-67-6 C₂₇H₃₄N₃O₄⁽¹⁺⁾*C₇H₇O₃S^(1-) 
• 1618136-72-3 2-(N-Boc-2-aminoethoxy)ethyl-9-hydroxy-6-methylellipticinium chloride 
• 1618136-76-7 2-(2-aminoethoxy)ethyl-9-hydroxy-6-methylellipticinium chloride 
• 1618136-81-4 C₂₄H₂₉N₄O₃⁽¹⁺⁾*Cl^(1-) 
• 1618136-86-9 C₂₄H₂₈N₅O₄⁽¹⁺⁾*Cl^(1-) 
• 1618136-73-4 2-(N-Boc-5-aminopentyl)-9-hydroxy-6-methylellipticinium chloride 
• 1618136-77-8 2-(5-aminopentyl)-9-hydroxy-6-methylellipticinium chloride 
• 1618136-82-5 Cl^(1-)*C₂₅H₃₁N₄O₂⁽¹⁺⁾ 
• 1618136-87-0 C₂₅H₃₀N₅O₃⁽¹⁺⁾*Cl^(1-) 
• 1618136-69-8 C₂₈H₃₆N₃O₃⁽¹⁺⁾*C₇H₇O₃S^(1-) 

Relevant articles and documents

Synthesis and in vitro antitumor activity of novel 2-alkyl-5- methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium and 2-alkylellipticin-2-ium chloride derivatives

Twenty-one types of novel ellipticine derivatives and pyridocarbazoles (5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazoles) with a nitrosourea moiety, linked by an oxydiethylene unit at the 2 position, were synthesized, and their cytotoxicity against HeLa S-3 cells was evaluated. Some of these new compounds exhibited potent antitumor activity by comparison with that of ellipticine.

REGIOSPECIFIC C-9 SUBSTITUTION OF ELLIPTICINE DERIVATIVES

6-Methylellipticine (6) undergoes acylation at the C(9)-position, under Friedel Crafts reaction conditions.The C(9)-formyl compound (8) rearranges to the corresponding hydroxy derivative (9) upon treatment with hydrogen peroxide, in methanol, in the presence of sulphuric acid.The two steps provide a convenient procedure for the specific C(9)-hydroxylation of the ellipticine template.

9-Acyloxy-5,11-dimethyl-6H-pyrido[4,3-B]carbazoles

9-Acyloxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazoles of the formula SPC1 Wherein R1 is acyl and R2 is hydrogen or lower alkyl, are described. The end products actively inhibit the growth of transplantable tumors, and are therefore useful as cytostatic agents.