10371-86-5 Usage
Description
9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole is an Ochrosia alkaloid found in O. oppositifolia and O. sandwicensis Gray, primarily in the bark of these species. It forms light yellow crystals and exhibits an ultraviolet spectrum in ethanol with absorption maxima at 242, 275, 290, and 335 mil. The compound can be characterized as its hydrochloride salt, which has a melting point of 288-290°C after undergoing a change in crystal form at 255-265°C, or as its picrate salt, with a melting point of 273-275°C. The structure of this compound has been determined through the analysis of its mass spectrum fragmentation pattern.
Uses
Used in Pharmaceutical Industry:
9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole is used as a pharmaceutical compound for its potential therapeutic applications. The expression is: 9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole is used as a therapeutic agent for its potential medicinal properties.
Used in Chemical Research:
In the field of chemical research, 9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole serves as a valuable compound for studying the properties and behavior of alkaloids, particularly those found in Ochrosia species. The expression is: 9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole is used as a research compound for understanding the characteristics and interactions of alkaloids in chemical studies.
Used in Analytical Chemistry:
9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole can also be utilized in analytical chemistry for the development of new methods and techniques for the identification and quantification of similar alkaloids in various samples. The expression is: 9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole is used as an analytical standard for the development of identification and quantification methods in analytical chemistry.
Please note that the specific applications and industries mentioned above are inferred based on the general properties and characteristics of the compound. Further research and validation would be required to confirm these uses in practice.
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 7106, 2007 DOI: 10.1021/jo070774z
References
Buzas, Osowiecki, Schindler., Cornpt. Rend., 247, 1390 (1958)
Goodwin, Smith, Horning.,!. Arner. Chern. Soc., 81,1903 (1959)
Mass spectrum:
Loder., Austral. J. Chern., 19, 1947 (1966)
Synthesis:
Dalton et aI., Austral. J. Chern., 20, 2715 (1967)
Check Digit Verification of cas no
The CAS Registry Mumber 10371-86-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,3,7 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 10371-86:
(7*1)+(6*0)+(5*3)+(4*7)+(3*1)+(2*8)+(1*6)=75
75 % 10 = 5
So 10371-86-5 is a valid CAS Registry Number.
InChI:InChI=1/C18H16N2O.ClH/c1-10-15-9-19-7-6-13(15)11(2)18-17(10)14-8-12(21-3)4-5-16(14)20-18;/h4-9,20H,1-3H3;1H
10371-86-5Relevant articles and documents
Ellipticines and 9-acridinylamines as inhibitors of d-alanine:d-alanine ligase
Vehar, Bla?,Hrast, Martina,Kova?, Andreja,Konc, Janez,Mariner, Katherine,Chopra, Ian,O'Neill, Alex,Jane?i?, Du?anka,Gobec, Stanislav
, p. 5137 - 5146 (2011)
d-Alanine:d-alanine ligase (Ddl), an intracellular bacterial enzyme essential for cell wall biosynthesis, is an attractive target for development of novel antimicrobial drugs. This study focused on an extensive evaluation of two families of Ddl inhibitors encountered in our previous research. New members of both families were obtained through similarity search and synthesis. Ellipticines and 9-acridinylamines were both found to possess inhibitory activity against Ddl from Escherichia coli and antimicrobial activity against E. coli and Staphylococcus aureus. Ellipticines with a quaternary methylpyridinium moiety were the most potent among all studied compounds, with MIC values as low as 2 mg/L in strains with intact efflux mechanisms. Antimicrobial activity of the studied compounds was connected to membrane damage, making their development as antibacterial drug candidates unlikely unless analogues devoid of this nonspecific effect can be discovered.
Simple method for preparing ellipticine or substituted ellipticine
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Paragraph 0050; 0051; 0059; 0060, (2020/05/14)
The invention relates to a synthesis process for preparing ellipticine. Ellipticine is obtained through six steps of reaction and three steps of crystallization separation, the target product total yield is high, column chromatography separation is not needed for an intermediate product and the target product, and the method is particularly suitable for large-scale preparation.
Friedel-crafts cyclodehydration approach toward the synthesis of ellipti-cine and 9-methoxyellipticine
Ramkumar, Nagarajan,Raghavendra, Medishetty S.,Nagarajan, Rajagopal
, p. 2791 - 2793 (2015/01/09)
An expedient synthesis of biologically important pyrido[4,3-b]carbazole alkaloids, ellipticine and 9-methoxyellipticine, is reported. Our synthetic approach applies a key H3PO4-mediated Friedel-Crafts cyclodehydration to construct the pyridine core.
