5654-93-3

Basic information

• Product Name: 3-METHYL-7-AZAINDOLE
• Synonyms: 3-METHYL-7-AZAINDOLE;1H-Pyrrolo[2,3-b]pyridine, 3-methyl-;3-methyl-1H-pyrrolo[2,3-b]pyridine;3-Methylpyrrolo[2,3-b]pyridine;7-Azaskatole
• CAS NO: 5654-93-3
• Molecular Formula: C8H8N2
• Molecular Weight: 132.16
• Product Categories: Amines;Heterocycles;Indole Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Azaindoles
• Mol File: 5654-93-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 130.5-133 °C
• Boiling Point: 284.967 °C at 760 mmHg
• Flash Point: 127.264 °C
• Appearance: /
• Density: 1.187g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.01±0.20(Predicted)
• CAS DataBase Reference: 3-METHYL-7-AZAINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-7-AZAINDOLE(5654-93-3)
• EPA Substance Registry System: 3-METHYL-7-AZAINDOLE(5654-93-3)

Safety Data

• Hazardous Substances Data: 5654-93-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8N2/c1-6-5-10-8-7(6)3-2-4-9-8/h2-5H,1H3,(H,9,10)

Upstream product

• 756531-25-6 N-(3-ethyl-[2]pyridyl)-formamide 
• 1912-42-1 (1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid 
• 464180-71-0 C₉H₉N₅O 
• 10299-67-9 propionaldehyde pyridin-2-ylhydrazone 
• 4930-98-7 pyrid-2-ylhydrazine 
• 4649-09-6 1H-pyrrolo[2,3-b]pyridin-3-carbaldehyde 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 138343-75-6 tert-butyl (3-methylpyridin-2-yl)carbamate 
• 149489-03-2 tert-butyl (3-ethylpyridin-2-yl)carbamate 
• 4414-87-3 1H-Pyrrolo[2,3-b]pyridin-3-yl-acetonitrile 
• 5654-92-2 7-azagramine 
• 2402-77-9 2,3-dichloro-pyridine 
• 107-11-9 1-amino-2-propene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 464180-73-2 3,7-dimethyl-1H-pyrrolo[2,3-b]pyridine 
• 464180-72-1 1,3-dimethyl-7-azaindole 
• 688782-00-5 3-methyl-1H-pyrrolo[2,3-b]pyridin-7-oxide 
• 145934-57-2 2-chloro-3-methylpyrrolo-[2,3-b]pyridine 

Relevant articles and documents

Excited-state proton phototransfer in the (3-methyl-7-azaindole)-(7- azaindole) heterodimer

A molecule of 7-azaindole and another of 3-methyl-7-azaindole form a doubly hydrogen bonded heterodimer of Cs symmetry with a first electronic excited state a′ where the electronic excitation is highly localized on one of the molecular halves. Also, because the electronic excitation only increases the acidity of the pyrrole nucleus and the basicity of the pyridine nucleus in one of the two hydrogen bonds, the heterodimer undergoes single rather than double proton transfer.

Iridium-catalyzed methylation of indoles and pyrroles using methanol as feedstock

Iridium-catalyzed methylation of indoles and pyrroles using methanol as the methylating agent was achieved. This transformation takes place via a borrowing hydrogen methodology under an air atmosphere, which constitutes a direct route to 3-methyl-indoles and methyl-pyrroles.

4-(BENZOIMIDAZOL-2-YL)-THIAZOLE COMPOUNDS AND RELATED AZA DERIVATIVES

The invention relates to compounds of Formula (I) wherein ring A, X, (R1)n, R2, R3, R4, R4', R5, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.