5654-94-4

Basic information

• Product Name: 1H-octahydropyrrolo[3,4-b]pyridine
• Synonyms: 1H-octahydropyrrolo[3,4-b]pyridine;1,4-Diazabicyclononan;7-Azaindolizine;DL-1,4-Diazabicyclononane;Octahydropyrrolopyrazin
• CAS NO: 5654-94-4
• Molecular Formula: C₇H₁₄N₂
• Molecular Weight: 126.202
• Mol File: 5654-94-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 198.5 °C at 760 mmHg
• Flash Point: 87.1 °C
• Appearance: /
• Density: 0.95 g/cm³
• Vapor Pressure: 0.358mmHg at 25°C
• Refractive Index: 1.469
• PKA: 11.11±0.20(Predicted)
• CAS DataBase Reference: 1H-octahydropyrrolo[3,4-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-octahydropyrrolo[3,4-b]pyridine(5654-94-4)
• EPA Substance Registry System: 1H-octahydropyrrolo[3,4-b]pyridine(5654-94-4)

Safety Data

• Hazardous Substances Data: 5654-94-4(Hazardous Substances Data)

Usage

General Description

1H-octahydropyrrolo[3,4-b]pyridine, also known as norharmane, is a chemical compound with a complex structure that includes a pyrrolopyridine ring. It is a naturally occurring compound found in plants, animals, and human tissues, as well as being produced during the combustion of tobacco and other organic materials. Norharmane has been studied for its potential role as a neurotransmitter and its effects on the central nervous system, as well as its potential use as a psychoactive drug. It has also been investigated for its possible role in sleep disorders and its potential as a biomarker for various diseases. In addition, norharmane has been studied for its carcinogenic properties and its potential role in the formation of DNA adducts, which are associated with cancer development.

InChI:InChI=1/C7H14N2/c1-2-6-4-8-5-7(6)9-3-1/h6-9H,1-5H2

Upstream product

• 496943-53-4 3-(4-iodopentyl)-6-(3-ethyl-4-methylanilino)uracil 
• 68077-26-9 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 18184-75-3 6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 128740-14-7 (R,R)-8-benzyl-2,8-diazabicyclo[4.3.0]-nonane 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 442882-27-1 6-(4-methoxybenzyl)-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 4664-00-0 2,3-pyridinedicarboximide 

Downstream Products

• 128740-61-4 8-chloro-1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 151096-44-5 1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 1035271-43-2 methyl 4-(1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl)benzoate 
• 151213-42-2 [R,R]-2,8-diazabicyclo[4.3.0]nonane 
• 158060-81-2 2,8-diazabicyclo[4.3.0]nonane 

Relevant articles and documents

(S, S) - 2,8-diazabicyclo [4.3.0] nonane preparation method

The invention relates to a novel preparation method of (S,S)-2,8-diazabicyclo[4.3.0]. The method comprises the steps that: 2,3-pyridine dicarboxylic acid derivative and amide are subjected to condensation, such that 2,3-pyridine dicarboximide is formed; 2,3-pyridine dicarboximide is subjected to protection and hydrogenation reduction, such that 8-substituted-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane is produced; the product is reduced in a borohydride reduction system, such that 8-substituted-2,8-diazabicyclo[4.3.0]nonane is obtained; the product is subjected to optical-active organic acid resolution, such that 8-site protection group is removed, and the final product is obtained. Or, 2,3-pyridine dicarboximide is directly subjected to hydrogenation reduction, such that 7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane is produced; the product is directly reduced in a borohydride reduction system, such that 2,8-diazabicyclo[4.3.0]nonane is produced; the 2,8-diazabicyclo[4.3.0]nonane is subjected to optical-active organic acid resolution, such that the final product is directly obtained. The method provided by the invention is advantaged in simple reaction route. The raw materials are cheap and easy to obtain. The reaction conditions are mild and easy to control. The method is suitable for industrialized productions.

NOVEL COMPOUNDS

There is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.

8-vinyl- and 9-ethinyl-quinolone-carboxylic acids

The invention relates to new 8-vinyl- and 8-ethinylquinolonecarboxylic acids, process for their preparation, and antibacterial agents and feed additives containing them.