565446-50-6

Basic information

• Product Name: Carbamimidic acid, N-benzoyl-N'-[3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propyl]-, phenyl ester
• CAS NO: 565446-50-6
• Molecular Formula: C39H34N4O2
• Molecular Weight: 590.725
• Mol File: 565446-50-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamimidic acid, N-benzoyl-N'-[3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propyl]-, phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamimidic acid, N-benzoyl-N'-[3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propyl]-, phenyl ester(565446-50-6)
• EPA Substance Registry System: Carbamimidic acid, N-benzoyl-N'-[3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propyl]-, phenyl ester(565446-50-6)

Safety Data

• Hazardous Substances Data: 565446-50-6(Hazardous Substances Data)

Upstream product

• 81282-38-4 N-diphenoxymethylene benzamide 
• 195053-89-5 4-(3-aminopropyl)-1-(triphenylmethyl)-imidazole 
• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 
• 154312-79-5 1-trityl-4-(2-cyanoethyl)imidazole 
• 565446-44-8 3-(1-Trityl-1H-imidazol-4-yl)-propionitrile 
• 152030-49-4 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 195053-88-4 2-[3-(1-trityl-1H-imidazol-4-yl)propyl]isoindoline-1,3-dione 

Downstream Products

• 565446-52-8 N-benzoyl-N'-(2-hydroxy-ethyl)-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-69-7 N-[3-(4-benzenesulfonyl-5-oxy-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-67-5 N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-65-3 N-benzoyl-N'-[3-(5-oxy-4-phenyl-furazan-3-yloxy)-propyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-62-0 N-benzoyl-N'-[2-(5-oxy-4-phenyl-furazan-3-yloxy)-ethyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-64-2 N-benzoyl-N'-[3-(4-phenyl-furazan-3-yloxy)-propyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-60-8 N-benzoyl-N'-[2-(4-phenyl-furazan-3-yloxy)-ethyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-69-7 N-[3-(4-benzenesulfonyl-5-oxy-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-67-5 N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-65-3 N-benzoyl-N'-[3-(5-oxy-4-phenyl-furazan-3-yloxy)-propyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-62-0 N-benzoyl-N'-[2-(5-oxy-4-phenyl-furazan-3-yloxy)-ethyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-64-2 N-benzoyl-N'-[3-(4-phenyl-furazan-3-yloxy)-propyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-60-8 N-benzoyl-N'-[2-(4-phenyl-furazan-3-yloxy)-ethyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 

Relevant articles and documents

[3-(1H-Imidazol-4-yl)propyl]guanidines containing furoxan moieties: A new class of H3-antagonists endowed with NO-donor properties

Synthesis and pharmacological characterisation of a series of products obtained by coupling the H3-antagonist SKF 91486 through appropriate spacers with the NO-donor 3-phenylfuroxan-4-yloxy and 3-benzenesulfonylfuroxan-4-yloxy moieties, as well as with the corresponding furazan substructures, devoid of NO-donating properties, are reported. All the products were tested for their H3-antagonistic and H2-agonistic properties on electrically-stimulated guinea-pig ileum segments and guinea-pig papillary muscle, respectively. The whole series of compounds displayed good H3-antagonist behaviour and feeble partial H2-agonist activity. Among furoxan derivatives, the benzenesulfonyl hybrid 28, a good NO-donor, triggered a dual NO-dependent muscle relaxation and H3-antagonistic effect on guinea-pig intestine.