565446-52-8

Basic information

• Product Name: Benzamide, N-[[(2-hydroxyethyl)amino][[3-[1-(triphenylmethyl)-1H-imidazol-4-yl]prop yl]amino]methylene]-
• CAS NO: 565446-52-8
• Molecular Formula: C35H35N5O2
• Molecular Weight: 557.695
• Mol File: 565446-52-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[[(2-hydroxyethyl)amino][[3-[1-(triphenylmethyl)-1H-imidazol-4-yl]prop yl]amino]methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[[(2-hydroxyethyl)amino][[3-[1-(triphenylmethyl)-1H-imidazol-4-yl]prop yl]amino]methylene]-(565446-52-8)
• EPA Substance Registry System: Benzamide, N-[[(2-hydroxyethyl)amino][[3-[1-(triphenylmethyl)-1H-imidazol-4-yl]prop yl]amino]methylene]-(565446-52-8)

Safety Data

• Hazardous Substances Data: 565446-52-8(Hazardous Substances Data)

Upstream product

• 565446-50-6 1-benzoyl-2-phenyl-3-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-isourea 
• 141-43-5 ethanolamine 
• 195053-88-4 2-[3-(1-trityl-1H-imidazol-4-yl)propyl]isoindoline-1,3-dione 
• 195053-89-5 4-(3-aminopropyl)-1-(triphenylmethyl)-imidazole 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 152030-49-4 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol 
• 565446-44-8 3-(1-Trityl-1H-imidazol-4-yl)-propionitrile 
• 154312-79-5 1-trityl-4-(2-cyanoethyl)imidazole 
• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 
• 81282-38-4 N-diphenoxymethylene benzamide 
• 565446-50-6 1-benzoyl-2-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}-O-phenylisourea 

Downstream Products

• 565446-60-8 N-benzoyl-N'-[2-(4-phenyl-furazan-3-yloxy)-ethyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-62-0 N-benzoyl-N'-[2-(5-oxy-4-phenyl-furazan-3-yloxy)-ethyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-62-0 N-benzoyl-N'-[2-(5-oxy-4-phenyl-furazan-3-yloxy)-ethyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-60-8 N-benzoyl-N'-[2-(4-phenyl-furazan-3-yloxy)-ethyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 

Relevant articles and documents

H3 receptor ligands: New imidazole H3-antagonists endowed with NO-donor properties

Synthesis and pharmacological properties of a group of compounds obtained by coupling the H3-antagonist SKF 91486 with the NO-donor 3-phenylfuroxan-4-yloxy and 3-benzenesulfonylfuroxan-4-yloxy moieties, as well as with the corresponding furazan analogues, devoid of NO-donating properties, are reported. All the products were tested for their H3-antagonistic and H2-agonistic properties on electrically-simulated guinea-pig ileum segments and guinea-pig papillary muscle, respectively. All the synthesised compounds displayed good H3-antagonistic properties (pA2 range 7.02-8.49) while behaving only as weak partial H2-agonists. Derivative 28, the best NO-donor of the series, was able to trigger a dual NO-dependent muscle relaxation and H3-antagonistic effect on guinea-pig illeum.