56610-81-2Relevant articles and documents
Preparation method of 5-mercapto-1H-tetrazole compound
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Paragraph 0034; 0036-0043, (2019/11/04)
The invention relates to a preparation method of a 5-mercapto-1H-tetrazole compound shown in a formula (III), which comprises the following steps of: (1) dissolving disulfide in halogenated alkane, dropwise adding a chlorinating reagent at -5 to 0 DEG C, carrying out heat preservation reaction for 2-5 hours, and carrying out reduced pressure distillation at 5-10 DEG C to obtain chlorinated disulfide; (2) dissolving the chlorinated disulfide prepared in the step (1) in lower saturated monohydric alcohol, dissolving sodium azide in water, dripping a sodium azide solution at 20-30 DEG C, heatingto 50-65 DEG C after dripping, and carrying out heat preservation reaction for 2-5 hours; (3) evaporating the solution obtained in the step (2) at 40-45 DEG C under reduced pressure to remove the lower saturated monohydric alcohol, and adding halogenated alkane for extraction for three times to obtain a halogenated alkane extraction liquid; (4) concentrating and crystallizing the halogenated alkane extraction liquid prepared in the step (3), and filtering to obtain the 5-mercapto-1H-tetrazole compound. The preparation method has high yield, good product quality, convenient solvent recycling and low production cost.
Synthesis of hydroxyethyltetrazolethiol and etherified intermediates therefor
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, (2008/06/13)
By heating an N-(2-hydroxyethyl)dithiocarbamate ester protected at its hydroxy group as an ether in the presence of an azide, the corresponding 1-(protected hydroxyethyl)-1H-tetrazole-5-thiol is obtained, and then, if required, deprotecting the etheric protection to give an industrially useful chemical, 1-(2-hydroxyethyl)-1H-tetrazole-5-thiol.
7-Substituted-3-aminoalkyl-, acylaminoalkyl-, or hydroxyalkyl-substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof
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, (2008/06/13)
Cephalosporanic acid derivatives and preparation thereof having the following formula STR1 wherein R1 is hydrogen or acyl, and R2 is aminoalkyl-, acylaminoalkyl-, sulfoalkylaminoalkyl-, or hydroxyalkyl-substituted, N- or N and S-containing heterocyclic groups.