56613-60-6 Usage
Description
2-[(3-Oxo-3-phenyl-propyl)amino]acetic acid, also known as N-(3-Phenylpropionyl)glycine, is an organic compound with a unique structure that features an amino group attached to a phenylpropyl group with a carboxylic acid functional group. It is an off-white solid and has been identified for its potential applications in various fields.
Uses
Used in Diagnostic Applications:
2-[(3-Oxo-3-phenyl-propyl)amino]acetic acid is used as a diagnostic tool for the detection and identification of various organic acidemias and mitochondrial fatty acid β-oxidation defects. It is particularly useful in the diagnosis of medium-chain acyl-CoA dehydrogenase deficiency (MCAD) in patients who have ingested 3-phenylpropionic acid, as it can be detected in their urine.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[(3-Oxo-3-phenyl-propyl)amino]acetic acid is used as a key intermediate in the synthesis of various drugs and pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new medications with potential therapeutic applications.
Used in Chemical Research:
2-[(3-Oxo-3-phenyl-propyl)amino]acetic acid is also utilized in chemical research as a starting material or a reagent for the synthesis of various organic compounds. Its versatile structure allows for further functionalization and modification, enabling the development of new molecules with specific properties and applications.
Used in Analytical Chemistry:
As an analytical standard, 2-[(3-Oxo-3-phenyl-propyl)amino]acetic acid is employed in the calibration and validation of analytical instruments and methods. Its distinct chemical properties make it suitable for use as a reference compound in various analytical techniques, such as chromatography and mass spectrometry.
Check Digit Verification of cas no
The CAS Registry Mumber 56613-60-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,6,1 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 56613-60:
(7*5)+(6*6)+(5*6)+(4*1)+(3*3)+(2*6)+(1*0)=126
126 % 10 = 6
So 56613-60-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO3/c1-2-10(13)12(8-11(14)15)9-6-4-3-5-7-9/h3-7H,2,8H2,1H3,(H,14,15)
56613-60-6Relevant articles and documents
Isolation, synthesis and photochemical properties of almazolone, a new indole alkaloid from a red alga of Senegal
Guella, Graziano,N'Diaye, Ibrahima,Fofana, Mouhamadou,Mancini, Ines
, p. 1165 - 1170 (2006)
An indole alkaloid bearing an oxazolone ring, christened almazolone, has been isolated from a new collection of Haraldiophyllum sp. from Dakar (Senegal), as an 88:12 mixture of (Z)/(E) stereoisomers. The relative ratio could be modified under controlled p
Solid phase synthesis of acylglycine human metabolites
Perez-Pineiro, Rolando,Dong, Ying Wei,Wishart, David S.
body text, p. 6706 - 6708 (2010/06/12)
Acylglycines represents a large and important class of human metabolites. They are often used in medicine to identify fatty acid oxidation disorders. A highly efficient solid phase synthesis approach to obtain these clinically important compounds is devel
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants
Geurts, Muriel,Poupaert, Jacques H.,Scriba, Gerhard K. E.,Lambert, Didier M.
, p. 24 - 30 (2007/10/03)
Glycine is a small neutral amino acid exhibiting weak anticonvulsant activities in vivo. Recently, studies have demonstrated that N- (benzyloxycarbonyl)glycine (1) antagonized seizures superior to glycine in addition to activity in the maximal electroshock (MES) test, a convulsive model where glycine is inactive. In the present study a series of ester and amide derivatives of 1 as well as esters of N-(3-phenylpropanoyl)glycine (5) have been prepared. The compounds were evaluated in the MES test as well as in several chemically induced seizure models. Among the derivatives investigated, N-(benzyloxycarbonyl)glycine benzylamide (16) was the most potent compound exhibiting an anticonvulsant activity in the MES test comparable to the drug phenytoin. Median effective doses (ED50) of 4.8 and 11.6 mg/kg were determined at 30 min and 3 h after ip administration, respectively. Compound 16 also effectively suppressed tonic seizures in different chemically induced models such as the strychnine, 3- mercaptopropionic acid, and pentylenetetrazole tests. Moreover, the compound studied here did not show acute neurotoxicity in the rotorod test up to a dose of 150 mg/kg. It is concluded that N-(benzyloxycarbonyl)glycine amides, especially 16, are potent anticonvulsant agents.
