566915-67-1Relevant articles and documents
Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties
Simoni, Daniele,Rondanin, Riccardo,Baruchello, Riccardo,Rizzi, Michele,Grisolia, Giuseppina,Eleopra, Marco,Grimaudo, Stefania,Di Cristina, Antonietta,Pipitone, Maria Rosaria,Bongiorno, Maria Rita,Aricò, Mario,Invidiata, Francesco Paolo,Tolomeo, Manlio
experimental part, p. 4796 - 4803 (2009/07/25)
A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing the carboxylic function have been found with the highest cell protective activity within the series, in complete and in serum-free conditions. Inhibition of apoptosis induced by daunorubicin has also been observed for the most active compound.