5731-11-3

Basic information

• Product Name: 4'-BROMO-4-BIPHENYL CARBOXYLIC ACID
• Synonyms: 4'-BROMO-4-BIPHENYL CARBOXYLIC ACID;4'-BROMO[1,1'-BIPHENYL]-4-CARBOXYLIC ACID;4-(4'-BROMOPHENYL)BENZOIC ACID;AKOS BAR-2384;Bromo biphenyl carboxylic acid;4'-Bromo-4-carboxybiphenyl, 4-(4-Bromophenyl)benzoic acid
• CAS NO: 5731-11-3
• Molecular Formula: C₁₃H₉BrO₂
• Molecular Weight: 277.11
• Mol File: 5731-11-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 301-302°C
• Boiling Point: 418.1°Cat760mmHg
• Flash Point: 206.7°C
• Appearance: /
• Density: 1.51g/cm³
• PKA: 4.08±0.10(Predicted)
• CAS DataBase Reference: 4'-BROMO-4-BIPHENYL CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-BROMO-4-BIPHENYL CARBOXYLIC ACID(5731-11-3)
• EPA Substance Registry System: 4'-BROMO-4-BIPHENYL CARBOXYLIC ACID(5731-11-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 5731-11-3(Hazardous Substances Data)

Usage

Uses

4''-Bromo[1,1''-biphenyl]-4-carboxylic Acid functions as a novel A-C ring steroidomimetic inhibitors of 5α-reductase (5αR) type 1 and 2.

Upstream product

• 109-72-8 n-butyllithium 
• 92-86-4 4-(4-bromophenyl)bromobenzene 
• 201230-82-2 carbon monoxide 
• 589-87-7 1,4-bromoiodobenzene 
• 180516-87-4 4-carboxyphenylboronic acid pinacol ester 

Downstream Products

• 586-76-5 4-Bromobenzoic acid 
• 89901-03-1 methyl 4’-bromo-[1,1’-diphenyl]-4-carboxylate 
• 5728-46-1 4′‐cyano‐[1,1′‐biphenyl]‐4‐carboxylic acid 
• 92-92-2 biphenyl-4-carboxylic acid 
• 566915-67-1 3-adamantan-1-yl-4-benzyloxy-[1,1';4',1'']terphenyl-4''-carboxylic acid 

Relevant articles and documents

Azabenzimidazole tetrahydrofuran derivatives

Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

Synthesis of aromatic carboxylic acids by carbonylation of aryl halides in the presence of epoxide-modified cobalt carbonyls as catalysts

A new procedure was developed for synthesis of aromatic and heteroaromatic acids and their derivatives (esters, salts) by carbonylation of the corresponding aryl halides. The acids are selectively formed in a high yield under very mild conditions. Highly active catalytic systems, base-containing alcoholic solutions of cobalt carbonyl modified with epoxides, were used to activate aryl halides. 2005 Pleiades Publishing, Inc.