56830-41-2

Basic information

• Product Name: Cyclohexanecarbonitrile, 2,2-dimethyl-5-oxo-
• CAS NO: 56830-41-2
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• Mol File: 56830-41-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Cyclohexanecarbonitrile, 2,2-dimethyl-5-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarbonitrile, 2,2-dimethyl-5-oxo-(56830-41-2)
• EPA Substance Registry System: Cyclohexanecarbonitrile, 2,2-dimethyl-5-oxo-(56830-41-2)

Safety Data

• Hazardous Substances Data: 56830-41-2(Hazardous Substances Data)

Upstream product

• 1073-13-8 4,4-dimethylcyclohexenone 
• 151-50-8 potassium cyanide 
• 5804-85-3 diethylaluminium cyanide 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 

Downstream Products

• 623563-89-3 cis-5-hydroxy-2,2-dimethylcyclohexanecarbonitrile 
• 92945-38-5 aethyl(2,2-dimethyl-5-oxocyclohexyl)keton 
• 294618-81-8 3-[(benzyloxycarbonyl)amino]-4,4-dimethylcyclohexanone 
• 294618-82-9 5-[(benzyloxycarbonyl)amino]-4,4-dimethylaminocyclohex-2-en-1-one 
• 623563-89-3 3-Cyano-4,4-dimethylcyclohexanol 

Relevant articles and documents

Synthesis of dimeric and tetrameric macrolactams with cytotoxic activity

Cyclization of amino acid 14, in turn prepared from 4,4-dimethylcyclohex-2-en-1-one by standard chemistry, yielded the dimeric and tetrameric macrolactams 15 and 16, respectively, representing the first examples of 'taxoid-like' compounds with heterocycli

Formaldehyde dialkylhydrazones as neutral formyl anion and cyanide equivalents: Nucleophilic addition to conjugated enones

A versatile methodology for the nucleophihc formylation and cyanation of conjugated enones is reported. The procedure is based on the use of formaldehyde dimethylhydrazone, which, acting as a neutral formyl anion equivalent, adds to preformed trialkylsilyl-enone complexes. Both 4-(silyl- oxy)-3-enal hydrazones 3 or deprotected 4-oxo aldehyde monohydrazones 4 can be obtained at products depending on quenching conditions. In full analogy, an asymmetric version of the reaction using chiral formaldehyde SAMP- hydrazone as a neutral synthon of the chiral formyl anion has been developed, giving rise to the corresponding adducts 5 and 6 in good yields and with excellent diastereoselectivities (de 85-≤98%). Ozonolysis or HCl-mediated hydrolysis of adducts 4 and 6 readily affords racemic and optically enriched 4-oxo aldehydes 7, respectively. Additionally, high-yielding MMPP-oxidative cleavage of 4-oxo hydrazones 4 and 6 has been performed to obtain 4-oxo nitriles 8 in racemic and optically enriched forms, respectively. In this way, interesting chiral bifunctional building blocks, some of them bearing newly created stereogenic quaternary centers, have been efficiently synthesized.

THE SYNTHESIS OF 3-ACYL-4,4-DIMETHYLCYCLOHEXA-2,5-DIENONES AND RELATED CYCLOHEXANONES

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