56877-43-1

Basic information

• Product Name: Z-DL-GLA(OTBU)2-OH
• Synonyms: Z-GAMMA-CARBOXY-GAMMA-(DI-T-BUTYL ESTER)-DL-GLUTAMIC ACID;Z-GAMMA-CARBOXY-DL-GLU(OTBU)2-OH;Z-GAMMA-CARBOXY-DL-GLUTAMIC ACID(OTBU)2-OH;Z-DL-GLA(OTBU)2-OH;Z-DL-Gla(otbu)-OH;Z-g-carboxy-DL-Glu(OtBu)2-OH;Z-γ-carboxy-γ-(di-tert-butyl ester)-DL-glutamic acid;Z-gamma-carboxy-gamma-(di-tert-butyl ester)-DL-glutamic acid
• CAS NO: 56877-43-1
• Molecular Formula: C₂₂H₃₁NO₈
• Molecular Weight: 437.48
• Mol File: 56877-43-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 582.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.188±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.59±0.10(Predicted)
• CAS DataBase Reference: Z-DL-GLA(OTBU)2-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-DL-GLA(OTBU)2-OH(56877-43-1)
• EPA Substance Registry System: Z-DL-GLA(OTBU)2-OH(56877-43-1)

Safety Data

• Hazardous Substances Data: 56877-43-1(Hazardous Substances Data)

Usage

General Description

Z-DL-GLA(OTBU)2-OH is a chemical compound that consists of a Z-DL-glutamyl dipeptide ester with two O-tert-butyl groups attached to the glutamic acid residue and a hydroxyl group at the C-terminus. Z-DL-GLA(OTBU)2-OH is often used in peptide synthesis and can act as a building block for more complex peptides. The Z-DL-GLA(OTBU)2-OH molecule is stable and can efficiently protect the carboxyl group of the glutamic acid residue, making it a useful tool for creating peptide chains with specific sequences and structures. Additionally, the tert-butyl groups provide protection for the side chains of the amino acids, allowing for controlled reactions and manipulations during peptide synthesis.

Upstream product

• 541-16-2 t-butyl malonate 
• 21142-81-4 methyl N-[(benzyloxy)carbonyl]-O-tosyl-L-serinate 
• 56877-43-1 Z-DL-Gla(OtBu)2-OH 
• 56877-40-8 Z-γ,γ,-di-tert-butyl-D,L-carboxyglutamic acid methyl ester 
• 1492-52-0 methyl (S)-2-(benzyloxycarbonlamino)-3-(p-toluenesulfonyl)propionate 
• 21149-17-7 methyl 2-(benzyloxycarbonylamino)acrylate 
• 62965-15-5 methyl 2-(R)-(benzyloxycarbonylamino)-3-bromomethylpropionate 
• 56877-38-4 methyl N-((benzyloxy)carbonyl)-3-iodo-L-alaninate 

Downstream Products

• 66513-60-8 N-(benzyloxycarbonyl)-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid α-methyl ester 
• 60686-50-2 N-(benzyloxycarbonyl)-γ,γ-di-tert-butyl-L-γ-carboxyglutamic acid 
• 56877-43-1 N-(benzyloxycarbonyl)-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid 
• 56877-44-2 γ,γ'-Di-tert-butyl-DL-γ-carboxyglutamic acid 
• 74219-73-1 N-benzyloxycarbonyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid methyl ester 
• 64153-42-0 Z-(D)Glu(OtBu)(γ-COOtBu)-Leu-OBzl 
• 111662-65-8 Fmoc-D-Gla(OtBu)2-OH 
• 74201-25-5 N-(benzyloxycarbonyl)-D-γ-carboxyglutamyl-D-γ-carboxyglutamic acid methyl ester 
• 80954-41-2 N-(benzyloxycarbonyl)-D-γ-methyleneglutamic acid α-methyl ester 
• 80954-39-8 N-(benzyloxycarbonyl)-D-γ-carboxyglutamic acid α-methyl ester 
• 66513-61-9 2-((R)-2-Benzyloxycarbonylamino-2-hydrazinocarbonyl-ethyl)-malonic acid di-tert-butyl ester 
• 53445-96-8 D(-)-γ-Carboxy-glutaminsaeure 
• 56271-99-9 2-amino-4-carboxypentanedioic acid 
• 53861-57-7 γ-carboxy-L-glutamic acid 

Relevant articles and documents

Enzymatic resolution of Z-γ,γ1-di-tert-butyl-D,L-carboxyglutamic acid methyl ester

A rapid and simple method for the resolution of Z-γ,γ1-di-tert-butyl-D,L-carboxyglutamic acid methyl ester is described. The new procedure is based on the enzymatic enantioselective saponification of the methyl ester by the endoprotease papain.

Improved chemical synthesis of optically pure N-(9-fluorenylmethoxycarbonyl)-γ,γ′-di-tert-butyl-γ- carboxyglutamic acid

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Crystalline derivatives of D,L-gamma-carboxyglutamic acid-gamma, gamma'-di-t-butylesters

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