56892-71-8

Basic information

• Product Name: 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride
• Synonyms: 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride
• CAS NO: 56892-71-8
• Molecular Weight: 425.447
• Mol File: 56892-71-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride(56892-71-8)
• EPA Substance Registry System: 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride(56892-71-8)

Safety Data

• Hazardous Substances Data: 56892-71-8(Hazardous Substances Data)

Upstream product

• 19741-14-1 4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid 
• 543-27-1 isobutyl chloroformate 

Downstream Products

• 124126-66-5 α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate 
• 80407-76-7 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-carbobenzoxy-L-ornithine tert-butyl ester 
• 80407-75-6 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine tert-butyl ester 
• 73610-81-8 N-methylamino>benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamic acid 
• 80407-56-3 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-lysine 
• 80407-73-4 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-ornithine 
• 51865-82-8 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine 
• 96846-20-7 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-ornithine trifluoroacetate 
• 51865-81-7 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-lysine hydrobromide 
• 80407-74-5 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-carbobenzoxy-L-ornithine 

Relevant articles and documents

Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase

Five analogues of methotrextate (MTX), 10-deazaaminopterin (10-DAM), and 10-ethyl-10-deazaaminopterin (10-EDAM) in which the glutamate moiety was replaced by either a γ-methyleneglutamate or β-hydroxyglutamate were synthesized and evaluated for their anti

Lysine and Ornithine Analogues of Methotrexate as Inhibitors of Dihydrofolate Reductase

The ornithine (6a) and lysine (6b) analogues of methotrexate (1) have been synthesized via condensation of 4-amino-4-deoxy-N10-methylpteroic acid (2) with Nδ-carbobenzoxy-L-ornithine tert-butyl ester (3a) and Nε-carbobenzo