80407-56-3

Basic information

• Product Name: lysine-methotrexate
• Synonyms: lysine-methotrexate
• CAS NO: 80407-56-3
• Molecular Formula: C₂₁H₂₇N₉O₃
• Molecular Weight: 453.49758
• Mol File: 80407-56-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.411g/cm³
• Refractive Index: 1.71
• CAS DataBase Reference: lysine-methotrexate(CAS DataBase Reference)
• NIST Chemistry Reference: lysine-methotrexate(80407-56-3)
• EPA Substance Registry System: lysine-methotrexate(80407-56-3)

Safety Data

• Hazardous Substances Data: 80407-56-3(Hazardous Substances Data)

Usage

Uses

Lysine-methotrexate is a derivative of Methotrexate (M260675), a folic acid antagonist.

InChI:InChI=1/C21H27N9O3/c1-30(11-13-10-25-18-16(26-13)17(23)28-21(24)29-18)14-7-5-12(6-8-14)19(31)27-15(20(32)33)4-2-3-9-22/h5-8,10,15H,2-4,9,11,22H2,1H3,(H,27,31)(H,32,33)(H4,23,24,25,28,29)/t15-/m0/s1

Upstream product

• 56892-79-6 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine methyl ester 
• 51865-82-8 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine 
• 83399-36-4 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-(tert-butoxycarbonyl)-L-lysine tert-butyl ester 
• 19741-14-1 4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid 
• 13288-57-8 1,1-dimethylethyl N₆-{[(1,1-dimethylethyl)oxy]carbonyl}-L-lysinate hydrochloride 
• 56892-71-8 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride 
• 5978-22-3 N(ε)-benzoyloxycarbonyl-L-lysine tert-butyl ester hydrochloride 
• 80407-75-6 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine tert-butyl ester 
• 7532-09-4 methotrexate sodium salt 

Downstream Products

• 108772-62-9 Sodium; (S)-6-(2-chloro-acetylamino)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-hexanoate 
• 108743-12-0 Sodium; (S)-6-(2-bromo-acetylamino)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-hexanoate 
• 82339-36-4 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-(iodoacetyl)-L-lysine 

Relevant articles and documents

Synthesis and characterization of a fluorescent analogue of methotrexate

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Lysine and Ornithine Analogues of Methotrexate as Inhibitors of Dihydrofolate Reductase

The ornithine (6a) and lysine (6b) analogues of methotrexate (1) have been synthesized via condensation of 4-amino-4-deoxy-N10-methylpteroic acid (2) with Nδ-carbobenzoxy-L-ornithine tert-butyl ester (3a) and Nε-carbobenzo