5692-27-3

Basic information

• Product Name: Benzamide, N-(cyanomethyl)- (6CI,7CI,8CI,9CI)
• Synonyms: Benzamide, N-(cyanomethyl)- (6CI,7CI,8CI,9CI);benzoylamidoacetonitrile
• CAS NO: 5692-27-3
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• Product Categories: AMIDE
• Mol File: 5692-27-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 409.1°C at 760 mmHg
• Flash Point: 201.2°C
• Appearance: /
• Density: 1.146g/cm³
• Vapor Pressure: 6.65E-07mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: Benzamide, N-(cyanomethyl)- (6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(cyanomethyl)- (6CI,7CI,8CI,9CI)(5692-27-3)
• EPA Substance Registry System: Benzamide, N-(cyanomethyl)- (6CI,7CI,8CI,9CI)(5692-27-3)

Safety Data

• Hazardous Substances Data: 5692-27-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8N2O/c10-6-7-11-9(12)8-4-2-1-3-5-8/h1-5H,7H2,(H,11,12)

Upstream product

• 5813-81-0 hippuramide 
• 98-88-4 benzoyl chloride 
• 540-61-4 2-aminoacetonitrile 
• 13243-42-0 α-Benzoylamino-α-methylmercapto-acetonitril 
• 151-63-3 cyanomethylamine sulfate 
• 151-63-3 aminoacetonitrile neutral sulfate 
• 6011-14-9 2-aminoacetonitrile hydrochloride 
• 1600-27-7 mercury(II) diacetate 
• 151-50-8 potassium cyanide 
• 78134-74-4 (benzoylaminomethyl)triethylammonium chloride 
• 13243-41-9 benzylidene-(4-methylsulfanyl-2-phenyl-oxazol-5-yl)-amine 

Downstream Products

• 112657-32-6 2-benzoylamino-acetimidic acid methyl ester; hydrochloride 
• 119852-34-5 ethyl 2-benzoylaminoacetamidate hydrochloride 
• 55443-42-0 N-(2-amino-2-thioxoethyl)benzamide 
• 4433-71-0 2-benzoylamino-acetimidoyl chloride 
• 57461-32-2 cyclohexyl-2-benzoylaminoacetate 
• 190517-98-7 5-amino-2-phenyl-oxazole-4-carbaldehyde 
• 10450-13-2 2-(benzoylamino-methyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester 
• 34955-74-3 5-phenyl-1,2,4-oxadiazole-3-carboxamide 
• 5692-21-7 hippuramidine 
• 26348-52-7 (Z)-2-benzamido-3-phenyl-2-propenenitrile 
• 30057-98-8 N-benzoyl-N-benzylaminoacetonitrile 
• 24748-71-8 N-benzoylglycine ethyl dithio ester 
• 93247-74-6 N-(2-Phenyl-oxazol-5-yl)-oxalamic acid 
• 93217-33-5 ethyl N-(2-phenyloxazol-5-yl)-oxamate 

Relevant articles and documents

Synthesis of Imidazoles and Oxazoles via a Palladium-Catalyzed Decarboxylative Addition/Cyclization Reaction Sequence of Aromatic Carboxylic Acids with Functionalized Aliphatic Nitriles

We herein report an efficient approach for the assembly of multiply substituted imidazoles and oxazoles in a single-step manner. These transformations are based on a decarboxylation addition and annulation of readily accessible aromatic carboxylic acids a

Nickel-Catalyzed Construction of 2,4-Disubstituted Imidazoles via C–C Coupling and C?N Condensation Cascade Reactions

A convenient Ni(II)-catalyzed C?C and C?N cascade coupling reaction was developed to directly access various 2,4-disubstituted imidazoles. The reaction scope covers a variety of aryl and aliphatic substitutions, which demonstrate moderate-to-excellent yie

Promiscuity and selectivity in covalent enzyme inhibition: A systematic study of electrophilic fragments

Covalent ligand-target interactions offer significant pharmacological advantages. However, off-target reactivity of the reactive groups, which usually have electrophilic properties, must be minimized, and the selectivity of irreversible inhibitors is a crucial requirement. We therefore performed a systematic study to determine the selectivity of several electrophilic groups that can be used as building blocks for covalently binding ligands. Six reactive groups with modulated electrophilicity were combined with 11 nonreactive moieties, resulting in a small combinatorial library of 72 fragment-like compounds. These compounds were screened against a group of 11 enzyme targets to assess their selectivity and their potential for promiscuous binding to proteins. The assay results showed a considerably lower degree of promiscuity than initially expected, even for those members of the screening collection that contain supposedly highly reactive electrophiles.