5694-95-1

Basic information

• Product Name: 1,3-DIOXOLANE-2,2-DIETHANOL
• Synonyms: 2-[2-(2-HYDROXY-ETHYL)-[1,3]DIOXOLAN-2-YL]-ETHANOL;1,3-DIOXOLANE-2,2-DIETHANOL;2,2-Bis(2-hydroxyethyl)[1,3]dioxolane;2,2'-(1,3-Dioxolane-2,2-diyl)diethanol;2,2'-(1,3-Dioxolane-2,2-diyl)bis(ethan-1-ol)
• CAS NO: 5694-95-1
• Molecular Formula: C₇H₁₄O₄
• Molecular Weight: 162.18
• Mol File: 5694-95-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 427.9 °C at 760 mmHg
• Flash Point: 212.6 °C
• Appearance: /
• Density: 1.198 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,3-DIOXOLANE-2,2-DIETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIOXOLANE-2,2-DIETHANOL(5694-95-1)
• EPA Substance Registry System: 1,3-DIOXOLANE-2,2-DIETHANOL(5694-95-1)

Safety Data

• Hazardous Substances Data: 5694-95-1(Hazardous Substances Data)

Usage

General Description

1,3-Dioxolane-2,2-diethanol, also known as dioxolane, is a chemical compound with the molecular formula C6H12O3. It is a colorless liquid that is used as a solvent and as a reagent in organic synthesis. It is commonly used as a solvent in the production of pharmaceuticals, pesticides, and perfumes. It is also used as a stabilizer in some formulations. The chemical is considered to have low toxicity to humans and the environment, but caution should still be exercised when handling it, as it can irritate the skin and eyes. Additionally, it is flammable and should be stored and handled accordingly.

Upstream product

• 71022-90-7 diethyl 2,2'-(1,3-dioxolane-2,2-diyl)diacetate 
• 6506-31-6 dimethyl acetonedicarboxylate ethylene ketal 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 

Downstream Products

• 312326-47-9 2-[2-[2-(benzyloxy)ethyl]-1,3-dioxolan-2-yl]ethanol 
• 312326-48-0 [2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-acetaldehyde 
• 362624-06-4 (R)-1-[2-(2-Benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-but-3-en-2-ol 
• 362624-03-1 (E)-4-[2-(2-Benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-but-2-en-1-ol 
• 362624-04-2 {(2R,3R)-3-[2-(2-Benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-oxiranyl}-methanol 
• 362624-05-3 2-(2-Benzyloxy-ethyl)-2-((2R,3S)-3-iodomethyl-oxiranylmethyl)-[1,3]dioxolane 
• 362624-02-0 (E)-4-[2-(2-Benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-but-2-enoic acid ethyl ester 
• 362624-09-7 3-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-2-(tert-butyl-dimethyl-silanyloxy)-propionaldehyde 
• 362624-07-5 {1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-allyloxy}-tert-butyl-dimethyl-silane 
• 362624-10-0 3-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-2-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol 
• 362624-11-1 {2-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-1-methoxymethoxymethyl-ethoxy}-tert-butyl-dimethyl-silane 
• 362624-08-6 4-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-butane-1,2-diol 
• 362624-15-5 3-[(4S,6R)-6-((S)-2,4-Bis-benzyloxy-butyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-1-((7R,9R)-9-methoxymethoxymethyl-1,4,8-trioxa-spiro[4.5]dec-7-yl)-3-methyl-butan-2-one 
• 362624-14-4 (E)-2-[(4S,6R)-6-((S)-2,4-Bis-benzyloxy-butyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-6-{2-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxymethoxy-propyl]-[1,3]dioxolan-2-yl}-2-methyl-hex-4-en-3-one 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS INHIBITORS OF HPK1

This disclosure relates to heterocyclics as inhibitors of HPK1, in particular relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising said compound that useful for treatment of HPK1 mediated diseases and conditions such as cancer. (I)

Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca2+-activated K+ channels

Previously, quinolinium-based tetraazacyclophanes, such as UCL 1684 and UCL 1848, have been shown to be extraordinarily sensitive to changes in chemical structure (especially to the size of the cyclophane system) with respect to activity as potent non-peptidic blockers of the small conductance Ca 2+-activated K+ ion channels (SKCa). The present work has sought to optimize the structure of the linking chains in UCL 1848. We report the synthesis and SKCa channel-blocking activity of 29 analogues of UCL 1848 in which the central CH2 of UCL 1848 is replaced by other groups X or Y = O, S, CF2, CO, CHOH, CC, CHCH, CHMe to explore whether subtle changes in bond length or flexibility can improve potency still further. The possibility of improving potency by introducing ring substituents has also been explored by synthesizing and testing 25 analogues of UCL 1684 and UCL 1848 with substituents (NO2, NH2, CF 3, F, Cl, CH3, OCH3, OCF3, OH) in the 5, 6 or 7 positions of the aminoquinolinium rings. As in our earlier work, each compound was assayed for inhibition of the afterhyperpolarization (AHP) in rat sympathetic neurons, an action mediated by the SK3 subtype of the SK Ca channel. One of the new compounds (39, R7 = Cl, UCL 2053) is twice as potent as UCL 1848 and UCL 1684: seven are comparable in activity.

Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae

Survival of the human pathogen Streptococcus pneumoniae requires a functional mevalonate pathway, which produces isopentenyl diphosphate, the essential building block of isoprenoids. Flux through this pathway appears to be regulated at the mevalonate kina