57044-78-7

Basic information

• Product Name: Benzene, [(1E)-2-ethyl-1-hexenyl]-
• CAS NO: 57044-78-7
• Molecular Formula: C14H20
• Molecular Weight: 188.313
• Mol File: 57044-78-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, [(1E)-2-ethyl-1-hexenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [(1E)-2-ethyl-1-hexenyl]-(57044-78-7)
• EPA Substance Registry System: Benzene, [(1E)-2-ethyl-1-hexenyl]-(57044-78-7)

Safety Data

• Hazardous Substances Data: 57044-78-7(Hazardous Substances Data)

Upstream product

• 52812-56-3 (E)-2-ethyl-1-iodohex-1-ene 
• 3220-49-3 phenyl copper 
• 1080-32-6 O,O-diethyl benzylphosphonate 
• 106-35-4 heptan-3-one 
• 74-85-1 ethene 
• 1129-65-3 (hex-1-yn-1-yl)benzene 
• 100-59-4 phenylmagnesium chloride 
• 109-72-8 n-butyllithium 
• 622-76-4 1-phenyl-1-butyne 
• 693-03-8 n-butyl magnesium bromide 
• 1007-32-5 benzyl ethyl ketone 
• 197139-52-9 trifluoromethanesulfonic acid 1-benzylidenepropyl ester 
• 67-56-1 methanol 
• 126979-60-0 3-(triphenylmethyl)heptane 

Relevant articles and documents

Iron-copper cooperative catalysis in the reactions of alkyl grignard reagents: Exchange reaction with alkenes and carbometalation of alkynes

Iron-copper cooperative catalysis is shown to be effective for an alkene-Grignard exchange reaction and alkylmagnesiation of alkynes. The Grignard exchange between terminal alkenes (RCH=CH2) and cyclopentylmagnesium bromide was catalyzed by FeCl3 (2.5 mol %) and CuBr (5 mol %) in combination with PBu3 (10 mol %) to give RCH2CH 2MgBr in high yields. 1-Alkyl Grignard reagents add to alkynes in the presence of a catalyst system consisting of Fe(acac)3, CuBr, PBu3, and N,N,N″,N″-tetramethylethylenediamine to give β-alkylvinyl Grignard reagents. The exchange reaction and carbometalation take place on iron, whereas copper assists with the exchange of organic groups between organoiron and organomagnesium species through transmetalation with these species. Sequential reactions consisting of the alkene-Grignard exchange and the alkylmagnesiation of alkynes were successfully conducted by adding an alkyne to a mixture of the first reaction. Isomerization of Grignard reagents from 2-alkyl to 1-alkyl catalyzed by Fe-Cu also is applicable as the first 1-alkyl Grignard formation step.

Manganese-catalyzed cross-coupling reaction between aryl grignard reagents and alkenyl halides

(Chemical Equation Presented) Aryl Grignard reagents react stereospecifically with alkenyl halides in the presence of manganese chloride (10%) to afford good yields of cross-coupling products.

Highly Selective and Practical Alkyne-Alkyne Cross-Coupling Using Cp2ZrBu2 and Ethylene

Highly selective alkyne-alkyne cross coupling reactions were achieved using Cp2ZrBu2 and ethylene gas.First, alkynes were treated with 1.2 equiv of Cp2ZrBu2 (Negishi reagent) under ethylene gas to give zirconacyclopentenes with high selectivities.Subsequent addition of a second alkyne to the solution of zirconacyclopentenes at 50 deg C gave unsymmetrical zirconacyclopentadienes selectively.After hydrolysis unsymmetrical dienes were obtained in high yields.