57103-14-7

Basic information

• Product Name: 9H-Carbazole, 9-(4-fluorophenyl)-
• CAS NO: 57103-14-7
• Molecular Formula: C18H12FN
• Molecular Weight: 261.298
• Mol File: 57103-14-7.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: 9H-Carbazole, 9-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Carbazole, 9-(4-fluorophenyl)-(57103-14-7)
• EPA Substance Registry System: 9H-Carbazole, 9-(4-fluorophenyl)-(57103-14-7)

Safety Data

• Hazardous Substances Data: 57103-14-7(Hazardous Substances Data)

Upstream product

• 2113-51-1 2-iodobiphenyl 
• 371-40-4 4-fluoroaniline 
• 2052-07-5 2-Bromobiphenyl 
• 3296-02-4 p-azidofluorobenzene 
• 4688-76-0 2-Biphenylboronic acid 
• 615-43-0 2-iodophenylamine 
• 122-39-4 diphenylamine 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 437-25-2 (4-fluorophenyl)(diphenyl)amine 
• 1016-05-3 dibenzothiophene sulfone 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 86-74-8 9H-carbazole 
• 90-41-5 2-phenylaniline 
• 86-00-0 2-nitrobiphenyl 

Downstream Products

• 1222558-52-2 3,6-diiodo-9-(4-fluoro-phenyl)-9H-carbazole 
• 934704-43-5 (4-(9H-carbazol-9-yl)phenyl)diphenylphosphine oxide 
• 1385028-98-7 C₄₁H₂₅F₂N₃ 
• 1361227-56-6 N-(4-fluorophenyl)-3,6-bis[3,6-tert-butyl-(carbazol-9-yl)]-carbazole 
• 1263366-29-5 N-(4-fluorophenyl)-3,6-bis(carbazol-9-yl)-carbazole 
• 1246261-65-3 4,4'-bis(9-(p-fluorophenyl)-9H-carbazol-3-yl)-1,1'-binaphthyl 

Relevant articles and documents

Method for synthesizing carbazole derivative

The invention aims to provide a method for synthesizing a carbazole derivative. The method is characterized in that palladium chloride is used as a catalyst, 2, 2' - dibromobiphenyl is used as an electrophilic reagent, primary amine is taken as a nucleophile, and the carbazole derivative is directly cross-coupled under the conditions of toluene as a solvent and an air atmosphere. The method has the advantages of high yield, high selectivity, simplicity and convenience in operation and the like.

Palladium-catalyzed C-H bond activation for the assembly of: N -aryl carbazoles with aromatic amines as nitrogen sources

A convenient and efficient palladium-catalyzed C-H bond activation for the assembly of N-aryl carbazole is reported, in which two C-N bonds were formed under one set of conditions. The desired carbazoles were achieved in decent yields with a wide substrate scope by utilizing readily available 2-iodo biphenyls and aromatic amines as starting materials.

Design, synthesis and biological evaluation of: N -arylsulfonyl carbazoles as novel anticancer agents

In this work, a set of structurally diverse synthetic carbazoles was screened for their anticancer activities. According to structure-activity relationship studies, carbazoles with an N-substituted sulfonyl group exhibited better anticancer activity. Moreover, compound 8h was discovered to show the most potent anticancer effects on Capan-2 cells by inducing apoptosis and cell cycle arrest in G2/M phase. Finally, the in vivo study demonstrated that 8h prevented the tumor growth in PANC-1 and Capan-2 xenograft models without apparent toxicity.