57162-60-4

Basic information

• Product Name: 4-(2'-methylphenyl)-2,6-diphenylpyridine
• Synonyms: 4-(2'-methylphenyl)-2,6-diphenylpyridine
• CAS NO: 57162-60-4
• Molecular Weight: 321.422
• Mol File: 57162-60-4.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 4-(2'-methylphenyl)-2,6-diphenylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2'-methylphenyl)-2,6-diphenylpyridine(57162-60-4)
• EPA Substance Registry System: 4-(2'-methylphenyl)-2,6-diphenylpyridine(57162-60-4)

Safety Data

• Hazardous Substances Data: 57162-60-4(Hazardous Substances Data)

Upstream product

• 79-46-9 2-nitropropane 
• 22966-01-4 2-methyl-trans-chalcone 
• 98-85-1 1-Phenylethanol 
• 89-95-2 2-methyl-benzyl alcohol 
• 95-47-6 o-xylene 
• 19433-17-1 acetophenone O-acetyloxime 
• 16619-28-6 1-phenyl-3-o-methylphenyl-2-propen-1-one 
• 89-93-0 ortho-methylbenzylamine 
• 536-74-3 phenylacetylene 
• 98-86-2 acetophenone 
• 618-36-0 rac-methylbenzylamine 
• 172264-69-6 1-(2-methylphenyl)-3-phenylprop-2-yn-1-one 
• 113-00-8 guanidine nitrate 
• 529-20-4 2-methylphenyl aldehyde 

Relevant articles and documents

TMSOTf-mediated Kr?hnke pyridine synthesis using HMDS as the nitrogen source under microwave irradiation

An efficient protocol for the preparation of pyridine skeletons has been successfully developed involving the TMSOTf/HMDS (trifluoromethanesulfonic acid/hexamethyldisilane) system for the intermolecular cyclization of chalcones under MW (microwave) irradiation conditions. This method provides a facile approach to synthesize 2,4,6-triaryl or 3-benzyl-2,4,6-triarylpyridines in good to excellent yields. Interestingly, the 2,6-diazabicyclo[2.2.2]oct-2-ene core was obtained by changing the acid additive to Sn(OTf)2, and the desired product was also confirmed using X-ray single-crystal diffraction analysis.

Method for synthesizing pyridine ring structure by utilizing cascade reaction of aldehyde, arylboronic acid and acetonitrile

The invention discloses a method for synthesizing a pyridine ring structure by utilizing cascade reaction of aldehyde, arylboronic acid and acetonitrile, which comprises the following steps: dissolving a palladium catalyst, aldehyde, arylboronic acid, a l

Merrifield resin-supported quinone as an efficient biomimetic catalyst for metal-free, base-free, chemoselective synthesis of 2,4,6-trisubstituted pyridines

Metal-free, base-free, biomimetic and chemoselective synthesis of 2,4,6-trisubstituted pyridines was developed under mild conditions for the first time. The heterogeneous biomimetic catalyst-recoverable Merrifield resin-supported quinone-was fully characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectrometry (XPS) and energy dispersive X-ray spectroscopy (EDX). This supported quinone catalyst exhibited excellent catalytic reactivity for chemoselective synthesis of 2,4,6-trisubstituted pyridines, providing an efficient and green method for the synthesis of pyridine derivatives under mild conditions. Mechanistic investigations were conducted to gain insights into the heterogeneous biomimetic catalyst as well as the resulting transformation. The successful capture of intermediates offered direct and clear evidence for the proposed mechanism.