5725-96-2Relevant articles and documents
Method for coproducing vasoxine hydrochloride and N,O-dimethylhydroxylamine hydrochloride
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Paragraph 0042-0048, (2017/04/03)
The invention relates to the technical field of compound synthesis methods, particularly a method for coproducing vasoxine hydrochloride and N,O-dimethylhydroxylamine hydrochloride. The method comprises the following steps: carrying out methylation reaction on hydroxylamine salt under alkaline conditions by using a methylating agent to obtain a reaction solution containing vasoxine and N,O-dimethylhydroxylamine, rectifying to separate a vasoxine bottom solution and an N,O-dimethylhydroxylamine crude distillate, respectively adding hydrochloric acid for salification, concentrating and crystallizing under reduced pressure, cooling, carrying out vacuum filtration, recrystallizing with water or methanol, and drying to obtain the vasoxine hydrochloride product and N,O-dimethylhydroxylamine hydrochloride product. The method has the advantages of simple and reliable technique, high product quality, high total yield and low comprehensive cost, and is more friendly to the environment and suitable for industrial production.
MANNICH BASE N-OXIDE DRUGS
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Page/Page column 65-66, (2008/12/07)
The invention relates to Mannich base N-oxides of drugs containing acidic N- H groups. Pharmaceutical compositions comprising therapeutically effective amount of Mannich base N-oxides, or a pharmaceutically acceptable salt or prodrug thereof, are disclosed. Further, the invention relates to methods of using the compounds, alone or in combination with one or more other active agents or treatments, are disclosed.
An antibody-catalyzed [2,3]-elimination reaction
Yoon, Seung Soo,Oei, Yoko,Sweet, Elizabeth,Schultz, Peter G.
, p. 11686 - 11687 (2007/10/03)
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