57287-24-8Relevant articles and documents
Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis
Hahn, Frank,Kandziora, Nadine,Friedrich, Steffen,Leadlay, Peter F.
, p. 634 - 640 (2014)
Herein, we describe the syntheses of a complex biosynthesis-intermediate analogue of the potent antitumor polyketide borrelidin and of reference molecules to determine the stereoselectivity of the dehydratase of borrelidin polyketide synthase module 3. Th
Stereoselective total synthesis of (-)-borrelidin
Vong, Binh G.,Kim, Sun Hee,Abraham, Sunny,Theodorakis, Emmanuel A.
, p. 3947 - 3951 (2007/10/03)
A convergent synthesis of (-)-borrelidin (1) is reported based on the retrosynthetic disconnections indicated in the picture. Highlights of the strategy include the construction of a strained enynone-containing macrolide and the installation of a cyano group in a regioselective manner by a novel molybdenum-catalyzed hydrostannation of the alkyne.