6453-07-2

Basic information

• Product Name: DIMETHYL 4-OXO-1,2-CYCLOPENTANEDICARBOXYLATE
• Synonyms: DIMETHYL 4-OXO-1,2-CYCLOPENTANEDICARBOXYLATE;4-OXO-CYCLOPENTANE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER;(1R,2R)-DIMETHYL 4-OXOCYCLOPENTANE-1,2-DICARBOXYLATE;1,2-Cyclopentanedicarboxylic acid, 4-oxo-, 1,2-dimethyl ester;Dimethyl 4-oxocyclopentane-1,2-dicarboxylate
• CAS NO: 6453-07-2
• Molecular Formula: C₉H₁₂O₅
• Molecular Weight: 200.18858
• Mol File: 6453-07-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 299°C at 760 mmHg
• Flash Point: 130.6°C
• Appearance: /
• Density: 1.247g/cm³
• Vapor Pressure: 0.00123mmHg at 25°C
• Refractive Index: 1.474
• CAS DataBase Reference: DIMETHYL 4-OXO-1,2-CYCLOPENTANEDICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIMETHYL 4-OXO-1,2-CYCLOPENTANEDICARBOXYLATE(6453-07-2)
• EPA Substance Registry System: DIMETHYL 4-OXO-1,2-CYCLOPENTANEDICARBOXYLATE(6453-07-2)

Safety Data

• Hazardous Substances Data: 6453-07-2(Hazardous Substances Data)

Usage

Description

DIMETHYL 4-OXO-1,2-CYCLOPENTANEDICARBOXYLATE is a colorless liquid chemical compound with the molecular formula C9H12O4. It is an ester formed from the condensation of dimethyl malonate and cyclopentanone, characterized by a fruity odor and low toxicity. However, it is flammable and can cause skin and eye irritation, requiring careful handling.

Uses

Used in Pharmaceutical Industry:
DIMETHYL 4-OXO-1,2-CYCLOPENTANEDICARBOXYLATE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the formation of complex molecular structures, enhancing the development of new drugs.
Used in Agrochemical Industry:
DIMETHYL 4-OXO-1,2-CYCLOPENTANEDICARBOXYLATE is used as an intermediate in the synthesis of agrochemicals, playing a role in the production of pesticides and other agricultural chemicals to improve crop protection and yield.
Used in Organic Synthesis:
DIMETHYL 4-OXO-1,2-CYCLOPENTANEDICARBOXYLATE is used as a reagent in organic synthesis, facilitating various chemical reactions and contributing to the creation of a wide range of organic compounds for different applications.

InChI:InChI=1/C9H12O5/c1-13-8(11)6-3-5(10)4-7(6)9(12)14-2/h6-7H,3-4H2,1-2H3/t6-,7-/m1/s1

Upstream product

• 67-56-1 methanol 
• 1703-61-3 rac-4-oxocyclopentane-1,2-dicarboxylic acid 
• 186581-53-3 diazomethane 
• 4534-68-3 (2S,3R)-1,2,3,4-butanetetracarboxylic acid 
• 1641-42-5 meso-butane-1,2,3,4-tetracarboxylic acid tetramethyl ester 
• 67885-96-5 2.3.4-Trimethoxycarbonylcyclopentanon 
• 1703-61-3 racemic trans-cyclopentanone-3,4-dicarboxylic acid 
• 37575-81-8 methyl trans-2-(methoxycarbonyl)-4-methylenecyclopentane-1-carboxylate 
• 16631-27-9 rac-trans-3,4-bis(methoxycarbonyl)hexanedioic acid 
• 16631-27-9 meso-3,4-bis(methoxycarbonyl)hexanedioic acid 
• 4534-68-3 1,2,3,4-butanetetracarboxylic acid 
• 4373-15-3 1,2,3,4-butanetetracarboxylic acid tetraethyl ester 
• 99837-73-7 4(S),1'(RS),2'(RS)-2,2-dimethyl-4-(2-carbomethoxy-4-methylenecyclopentyl)-1,3-dioxolane 
• 17673-68-6 dimethyl trans-cyclohex-4-ene-1,2-dicarboxylate 

Downstream Products

• 35079-19-7 trans-(1R,2R)-1,2-Bis(methoxycarbonyl)-4-oxocyclopentane 
• 115694-82-1 (1S,2S)-2-(methoxycarbonyl)-4-oxocyclopentanecarboxylic acid 
• 115794-30-4 (+)-(1S,2S)-dimethyl-4-oxocyclopentane 1,2-dicarboxylate 
• 194918-80-4 2,4-Dioxo-1,3-diaza-spiro[4.4]nonane-7,8-dicarboxylic acid 
• 195209-04-2 ACPT-II 
• 57287-24-8 (1R,2R)-1,2-(dihydroxymethyl)cyclopentane 
• 7184-60-3 borrelidin 
• 768395-26-2 {(1R,2R)-2-[(S)-1-(4-Methoxy-benzyloxy)-but-3-enyl]-cyclopentyl}-methanol 
• 768395-22-8 (1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopentanecarbaldehyde 
• 768395-42-2 [(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopentyl]-methanol 
• 768395-28-4 (S)-3-(4-Methoxy-benzyloxy)-3-[(1R,2R)-2-(2-methoxy-ethoxymethoxymethyl)-cyclopentyl]-propionaldehyde 
• 768395-27-3 1-Methoxy-4-{(S)-1-[(1R,2R)-2-(2-methoxy-ethoxymethoxymethyl)-cyclopentyl]-but-3-enyloxymethyl}-benzene 

Relevant articles and documents

THIENOPYRIMIDINE DERIVATIVE AND USE THEREOF IN MEDICINE

The present invention relates to a thienopyrimidine derivative and use thereof in medicine, and also to a pharmaceutical composition containing the compound. The compound or pharmaceutical composition is used for inhibiting acetyl-CoA carboxylase (ACC). The present invention also relates to a method of preparing such compound and pharmaceutical composition, as well as their use in the treatment or prevention of diseases regulated by acetyl-CoA carboxylase in mammals, especially in humans.

The Synthesis of Novel Trans-Oxabicyclo[3,3,0]octane Systems as Potential Inhibitors of HIV Protease

The novel trans-3-oxabicyclo[3,3.0]octan-7-one system has been prepared by intramolecular ring closure of the corresponding cyclopentane diol. Peralkylation and benzylidene substitution of the octanone has allowed the preparation of tetra-alkylated potential inhibitors of HIV protease. Weak activity against HIV protease (IC50's 70-100μM) was observed.

Synthesis of Enantiomerically Pure trans-3,4-Substituted Cyclopentanols by Enzymatic Resolution

-