573-26-2

Basic information

• Product Name: N-methyl-N-(2-methylphenyl)acetamide
• Synonyms: N-methyl-N-(2-methylphenyl)acetamide;N-Methyl-N-(o-tolyl)acetamide;N-methyl-N-(2-methylphenyl)ethanamide
• CAS NO: 573-26-2
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.21632
• EINECS: 209-353-7
• Mol File: 573-26-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 55.5°C
• Boiling Point: 290.31°C (rough estimate)
• Appearance: /
• Density: 1.0508 (rough estimate)
• Refractive Index: 1.5718 (estimate)
• PKA: 1.22±0.50(Predicted)
• CAS DataBase Reference: N-methyl-N-(2-methylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(2-methylphenyl)acetamide(573-26-2)
• EPA Substance Registry System: N-methyl-N-(2-methylphenyl)acetamide(573-26-2)

Safety Data

• Hazardous Substances Data: 573-26-2(Hazardous Substances Data)

Usage

General Description

N-methyl-N-(2-methylphenyl)acetamide is a chemical compound with the molecular formula C10H13NO. It is a derivative of acetamide, with a methyl group and a 2-methylphenyl group attached to the nitrogen atom. N-methyl-N-(2-methylphenyl)acetamide has various applications, including as a pharmaceutical intermediate, a chemical intermediate in the synthesis of other organic compounds, and as a reagent in chemical research. It is commonly used in organic synthesis and medicinal chemistry. The compound is a white to slightly yellow solid at room temperature and is soluble in both water and organic solvents. It is important to handle N-methyl-N-(2-methylphenyl)acetamide with care, as it may pose risks to human health and the environment.

InChI:InChI=1/C10H13NO/c1-8-6-4-5-7-10(8)11(3)9(2)12/h4-7H,1-3H3

Upstream product

• 108-24-7 acetic anhydride 
• 611-21-2 N,2-dimethylaniline 
• 120-66-1 N-(2-methylphenyl)acetamide 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 71-43-2 benzene 
• 95-53-4 o-toluidine 
• 609-72-3 N,N-dimethyl-o-toluidine 
• 201230-82-2 carbon monoxide 
• 75-36-5 acetyl chloride 
• 10387-40-3 potassium thioacetate 

Downstream Products

• 24106-05-6 4'-bromo-2'-methylacetanilide 
• 90490-46-3 4-bromo-N-bromoacetyl-N-methyl-2-tribromomethylaniline 
• 611-21-2 N,2-dimethylaniline 
• 15258-49-8 N-ethyl-N-methyl-2-methylaniline 

Relevant articles and documents

Method for preparing aryl amide compound by catalyzing carbonylation of aryl tertiary amine through metal-free catalytic system

The invention discloses a method for preparing aryl amide compounds by catalyzing aryl tertiary amine carbonylation through a metal-free catalytic system. The method is characterized in that in a reaction solvent, carbonyl molybdenum is used as a substitute carbonyl source, an organic base is used as a main catalyst, and methyl iodide is used as a catalyst promoter; and carbonylation of aryl tertiary amine is catalyzed under normal pressure to prepare the aryl amide compound. The reaction formula of synthesis is shown in the specification, wherein R is one of CH3, C2H5, pheyl, F, CL, Br or CN. According to the present invention, the organic base is adopted as the main catalyst, the iodomethane is adopted as the catalyst promoter, the carbonyl molybdenum is adopted as the substitute carbonyl source, and the aryl tertiary amine carbonylation can be efficiently catalyzed at the reaction temperature of 140 DEG C to prepare the aryl amide compound, so that the atom economy of the reaction is effectively improved, and a wide application prospect is provided; the molybdenum carbonyl is used as the substitute carbonyl source, so that the potential safety hazard of carbon monoxide is avoided; and the reaction can be carried out under normal pressure in the reaction process, and high-pressure reaction equipment is not needed.

Z-Selective Fluoroalkenylation of (Hetero)Aromatic Systems by Iodonium Reagents in Palladium-Catalyzed Directed C?H Activation

The direct and catalytic incorporation of fluorine containing molecular motifs into organic compounds resulting high-value added chemicals represents a rapidly evolving part of synthetic methodologies, thus this area is in the focus of pharmaceutical and agrochemical research. Herein we report a stereoselective procedure for direct fluorovinylation of aromatic and heteroaromatic scaffolds. This methodology development has been realized by palladium-catalyzed ortho C?H activation reaction of aniline derivatives featuring the regioselectivity via directing groups such as secondary of tertiary amides, ureas or ketones. The application of non-symmetrical aryl(fluoroalkenyl)-iodonium salts as fluoroalkenylating agents allowed mild reaction conditions in general for this transformation. The scope and limitations have been thoroughly investigated and the feasibility has been demonstrated by more than 50 examples.

The copper-catalyzed aerobic oxidative amidation of tertiary amines

A general and efficient method for the synthesis of tertiary amides has been developed via the copper-catalyzed aerobic oxidative amidation of tertiary amines. Due to the use of the O2 oxidant, various functional groups were well tolerated under the present conditions. Extensive substrates studies demonstrated its potential as a practical approach for the synthesis of tertiary amides.