573-46-6

Basic information

• Product Name: 2-BROMO-4'-FLUOROBENZOPHENONE
• Synonyms: 2-BROMO-4'-FLUOROBENZOPHENONE;UKRORGSYN-BB BBV-5117260;(2-broMophenyl)(4-fluorophenyl)Methanone
• CAS NO: 573-46-6
• Molecular Formula: C₁₃H₈BrFO
• Molecular Weight: 279.1
• Mol File: 573-46-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 352.2°C at 760 mmHg
• Flash Point: 166.8°C
• Appearance: /
• Density: 1.485g/cm³
• Vapor Pressure: 3.89E-05mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 2-BROMO-4'-FLUOROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4'-FLUOROBENZOPHENONE(573-46-6)
• EPA Substance Registry System: 2-BROMO-4'-FLUOROBENZOPHENONE(573-46-6)

Safety Data

• Hazardous Substances Data: 573-46-6(Hazardous Substances Data)

Usage

General Description

2-Bromo-4'-fluorobenzophenone is a chemical compound with the molecular formula C13H8BrFO. It is a white to off-white crystalline powder that is commonly used in organic synthesis and pharmaceutical research. 2-BROMO-4'-FLUOROBENZOPHENONE is classified as a benzophenone derivative, which is a type of aromatic ketone. 2-Bromo-4'-fluorobenzophenone is known for its unique chemical properties, including its high level of reactivity and its ability to undergo various types of chemical reactions. It is commonly used as a building block in the synthesis of other organic compounds and is also used as a starting material for the production of pharmaceutical drugs and agrochemicals. Additionally, this compound is also used as a photoinitiator in the production of photopolymers and in the formulation of UV-curable resins for coatings and adhesives.

InChI:InChI=1/C13H8BrFO/c14-12-4-2-1-3-11(12)13(16)9-5-7-10(15)8-6-9/h1-8H

Upstream product

• 2042-37-7 o-cyanobromobenzene 
• 59142-67-5 (2-bromophenyl)(4-fluorophenyl)methanol 
• 6630-33-7 ortho-bromobenzaldehyde 
• 352-13-6 4-flourophenylmagnesium bromide 
• 899425-05-9 2-bromo-N-methoxy-N-methylbenzamide 
• 88-65-3 2-bromobenzoic-acid 
• 583-55-1 1-Bromo-2-iodobenzene 
• 201230-82-2 carbon monoxide 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 438-61-9 2,2'-bis-(4-fluoro-benzoyl)-biphenyl 
• 68355-79-3 1-bromo-2-(4-fluorobenzyl)benzene 
• 1186678-00-1 (E)-1-bromo-2-[1-(4-fluorophenyl)-2-methoxyethenyl]benzene 
• 388-30-7 butyl 2-(4-fluorobenzoyl)benzoate 

Relevant articles and documents

Divergent Access to Benzocycles through Copper-Catalyzed Borylative Cyclizations

A copper-catalyzed chemodivergent approach to five- and six-membered benzocycles from dienyl arenes tethered with a ketone has been developed. Through proper choice of coordinating ligands and catalytic conditions, copper-catalyzed borylative cyclization of a single dienyl arene can be diverted to two different pathways, leading to indanols and dihydronaphthalenols with high stereoselectivity. The chiral bidentate bisphosphine ligand (S,S)-Ph-BPE was optimal for asymmetric copper-allyl addition to a tethered ketone via a boat-like transition state, whereas NHC ligands led to boro-allyl addition producing indanols with high diastereoselectivity. (Figure presented.).

Asymmetric Synthesis of 1,2-Dihydronaphthalene-1-ols via Copper-Catalyzed Intramolecular Reductive Cyclization

We describe a copper-catalyzed intramolecular reductive cyclization of easily accessible benz-tethered 1,3-dienes containing a ketone moiety. This process provided biologically active 1,2-dihydronaphthalene-1-ol derivatives in good yields with excellent enantio- and diastereoselectivity. Mechanistic investigations using density functional theory revealed that (Z)- and (E)-allylcopper intermediates formed in situ from the diene and copper catalyst undergo isomerization and selective intramolecular allylation of the (E)-allylcopper form of the major product through a six-membered boatlike transition state. The resulting products were further transformed to fully saturated naphthalene-1-ols by reactions of the olefin moiety.

Synthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes

The palladium catalyzed annulation of 1-bromo-2-vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes. A controllable aryl to vinylic 1,4-palladium migration process is the key for success.