57356-49-7

Basic information

• Product Name: N-Phenyl-2-pyrimidinamine
• Synonyms: N-Phenyl-2-pyrimidinamine;2-(Phenylamino)pyrimidine;2-Phenylaminopyrimidine;N-Phenylpyrimidine-2-amine;2-Anilinopyrirmidine;2-Anilinopyrimidine;N-phenylpyriMidin-2-aMine;phenyl-pyrimidin-2-yl-amine
• CAS NO: 57356-49-7
• Molecular Formula: C₁₀H₉N₃
• Molecular Weight: 171.2
• Product Categories: pharmacetical
• Mol File: 57356-49-7.mol
• Article Data: 32

Chemical Properties

• Melting Point: 115-116℃
• Boiling Point: 331.554 °C at 760 mmHg
• Flash Point: 154.319 °C
• Appearance: /
• Density: 1.206
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.00±0.10(Predicted)
• CAS DataBase Reference: N-Phenyl-2-pyrimidinamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Phenyl-2-pyrimidinamine(57356-49-7)
• EPA Substance Registry System: N-Phenyl-2-pyrimidinamine(57356-49-7)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 57356-49-7(Hazardous Substances Data)

Usage

Description

N-Phenyl-2-pyrimidinamine is an organic compound with the molecular formula C10H9N3. It is a derivative of pyrimidinamine, featuring a phenyl group attached to the nitrogen atom at the 2nd position. N-Phenyl-2-pyrimidinamine is known for its potential applications in various chemical and pharmaceutical industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
N-Phenyl-2-pyrimidinamine is used as an intermediate compound for the synthesis of various pharmaceutical products. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Chemical Industry:
In the chemical industry, N-Phenyl-2-pyrimidinamine is used as a building block for the preparation of nitrogen-containing heterocyclic compounds. These compounds have a wide range of applications, including the development of new materials with specific properties, such as improved stability, reactivity, or selectivity in various chemical reactions.
Used in Preparation of Nitrogen-containing Heterocyclic Hexafluoroborate:
N-Phenyl-2-pyrimidinamine is used as a starting material for the preparation of nitrogen-containing heterocyclic hexafluoroborate salts. These salts are important in the synthesis of various complex organic molecules and have potential applications in the development of new drugs, agrochemicals, and other specialty chemicals.

InChI:InChI=1/C10H9N3/c1-2-5-9(6-3-1)13-10-11-7-4-8-12-10/h1-8H,(H,11,12,13)

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 62-53-3 aniline 
• 624-67-9 Propargylic aldehyde 
• 6291-89-0 phenylguanidine carbonate 
• 52057-92-8 4-chloro-N-phenylpyrimidin-2-amine 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 2002-16-6 1-phenylguanidine 
• 275-03-6 tetrazolo[1,5-a]pyrimidine 
• 71-43-2 benzene 
• 7732-18-5 water 
• 4595-60-2 2-bromopyrimidine 
• 109-12-6 2-aminopyrimidine 
• 108-86-1 bromobenzene 
• 591-50-4 iodobenzene 

Downstream Products

• 84062-63-5 phenyl-(1,4,5,6-tetrahydro-pyrimidin-2-yl)-amine 
• 133062-54-1 1,2-dimethyl-4-N-ethylanilinopyrimidin-6-one 
• 1283073-98-2 2,3-diphenyl-1-(pyrimidin-2-yl)-1H-indole 
• 1359822-89-1 2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid 
• 1359822-93-7 (S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid 
• 1359822-96-0 (S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoic acid amide 
• 1359822-98-2 (S)-2-amino-3-(phenyl-pyrimidin-2-yl-amino)-propionamide 
• 1360589-53-2 (S)-1-phenylethyl-ammonium (S)-2-tert-butoxycarbonylamino-3-(phenyl-pyrimidin-2-ylamino)-propanoate 
• 1447064-68-7 1-(pyrimidin-2-yl)-2,3-di-p-tolyl-1H-indole 
• 1447064-72-3 2,3-bis(4-methoxyphenyl)-1-(pyrimidin-2-yl)-1H-indole 
• 1447064-76-7 2,3-bis(4-fluorophenyl)-1-(pyrimidin-2-yl)-1H-indole 
• 1447064-80-3 3-(tert-butyl)-1-(pyrimidin-2-yl)-2-{4-(trifluoromethyl)phenyl}-1H-indole 
• 1542247-76-6 1-acetyl-1-tert-butyl-3-phenyl-3-pyrimidin-2-yl-urea 
• 1542247-94-8 1-tert-butyl-3-phenyl-1-phenylacetyl-3-pyrimidin-2-yl-urea 

Relevant articles and documents

Pyrimidine-directed metal-free C-H borylation of 2-pyrimidylanilines: a useful process for tetra-coordinated triarylborane synthesis

Convenient, easily handled, laboratory friendly, robust approaches to afford synthetically important organoboron compounds are currently of great interest to researchers. Among the various available strategies, a metal-free approach would be overwhelmingl

Predictable site-selective functionalization: Promoter group assistedpara-halogenation ofN-substituted(hetero)aromatics under metal-free condition

Herein, regioselectivepara-C-H halogenation ofN-pyrimidyl (hetero)aromatics through SEAr (electrophilic aromatic substitution) type reaction is disclosed. SEAr type reaction has been utilized for the C5-bromination of indolines (para-selective) withN-bromosuccinimide under metal and additive-free conditions in good to excellent yields. The developed methodology is also applicable for iodination and challenging chlorination. The pyrimidyl group is identified as a reactivity tuner that also controls the regioselectivity. The present method is also applicable for selective halogenation of aniline, pyridine, indole, oxindole, pyrazole, tetrahydroquinoline, isoquinoline, and carbazole. DFT studies such as Fukui nucleophilicity and natural charge maps also support the observedp-selectivity. Post-functionalization of the title compound into the corresponding arylated, olefinated, and dihalogenated products is achieved in a one-pot, two-step fashion. Late-stage C-H bromination was also executed on drug/natural molecules (harmine, etoricoxib, clonidine, and chlorzoxazone) to demonstrate the applicability of the developed protocol.

PYRENE DERIVATIVES AND ORGANIC ELECTRO LUMINESCENT DEVICE COMPRISING SAME

The present invention relates to a pyrene based derivative compound of an asymmetric structure and an organic electroluminescent device comprising the same. The pyrene derivative according to the present invention is characterized by being represented by chemical formula A through chemical formula B. The pyrene derivative compound according to the present invention exhibits remarkably improved blue color purity as compared to an organic electroluminescent device using an existing pyrene based aryl amine derivative compound while being able to realize full color since life characteristic and luminance characteristic are excellent, thereby being able to be used in various display devices.