5737-83-7

Basic information

• Product Name: AKOS BAR-2394
• Synonyms: AKOS BAR-2394;3'-BROMOBIPHENYL-4-CARBOXYLIC ACID;OTAVA-BB 1179305;3'-Bromo-[1,1'-biphenyl]-4-carboxylic acid;3'-Bromo-4-carboxybiphenyl, 4-(3-Bromophenyl)benzoic acid
• CAS NO: 5737-83-7
• Molecular Formula: C₁₃H₉BrO₂
• Molecular Weight: 277.116
• Mol File: 5737-83-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AKOS BAR-2394(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS BAR-2394(5737-83-7)
• EPA Substance Registry System: AKOS BAR-2394(5737-83-7)

Safety Data

• Hazardous Substances Data: 5737-83-7(Hazardous Substances Data)

Usage

Uses

3''-Bromo[1,1''-biphenyl]-4-carboxylic Acid is a reagent used in the synthesis of terphenyl derivatives for the support of cell growth and inhibition of apoptosis in neuronals and HL-60 cells.

Upstream product

• 5730-89-2 4-acetyl-3'-bromobiphenyl 
• 89900-91-4 methyl 3-bromo[1,1'-biphenyl]-4-carboxylate 
• 400749-87-3 3’-bromobiphenyl-4-ylcarbaldehyde 
• 591-18-4 1-Bromo-3-iodobenzene 
• 87199-17-5 4-formylphenylboronic acid, 
• 2113-57-7 3-bromobiphenyl 

Downstream Products

• 89900-91-4 methyl 3-bromo[1,1'-biphenyl]-4-carboxylate 
• 5728-45-0 3'-cyano-[1,1'-biphenyl]-4-carboxylic acid 
• 566915-66-0 3-adamantan-1-yl-4-benzyloxy-[1,1';3',1'']terphenyl-4''-carboxylic acid 

Relevant articles and documents

Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties

A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing the carboxylic function have been found with the highest cell protective activity within the series, in complete and in serum-free conditions. Inhibition of apoptosis induced by daunorubicin has also been observed for the most active compound.

A convenient synthesis of unsymmetrically substituted terphenyls of biologically active stilbenes via a double Suzuki cross-coupling protocol

A double Suzuki cross-coupling protocol has been devised as a practical route to a variety of terphenyls. Good chemoselectivity was observed. Unsymmetrically substituted triphenylenes were also easily prepared.