577-53-7Relevant articles and documents
Enzymatic synthesis of a 6-sialyl lactose analogue using a pH-responsive water-soluble polymer support
Wang, Wenjun,Li, Lei,Jin, Chen,Niu, Yujie,Li, Sen,Ma, Ji,Li, Linfeng,Liu, Yu,Cai, Li,Zhao, Wei,Wang, Peng George
, p. 5041 - 5044 (2011/10/09)
The Letter describes a strategy for the enzymatic synthesis of glycans based on a pH-responsive water-soluble polymer. In neutral condition, the polymer is water-soluble and convenient for in-solution enzymatic synthesis, whereas in acidic condition (pH lower than 4.0), the polymer disconnects with the product and becomes insoluble, which can be easily removed. A 6-Sialyl lactose analogue was synthesized as a model reaction using this approach.