57775-01-6

Basic information

• Product Name: 4-(Methylthio)butyl azide
• Synonyms: 4-(Methylthio)butyl azide
• CAS NO: 57775-01-6
• Molecular Formula: C₅H₁₁N₃S
• Molecular Weight: 145.22594
• Product Categories: Aliphatics;Intermediates;Sulfur & Selenium Compounds
• Mol File: 57775-01-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: 4-(Methylthio)butyl azide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Methylthio)butyl azide(57775-01-6)
• EPA Substance Registry System: 4-(Methylthio)butyl azide(57775-01-6)

Safety Data

• Hazardous Substances Data: 57775-01-6(Hazardous Substances Data)

Usage

Description

4-(Methylthio)butyl azide is a light yellow oil with the chemical formula CH7NS3. It is an organic compound that belongs to the class of azides, which are characterized by the presence of a -N3 group. 4-(Methylthio)butyl azide is known for its reactivity and is commonly used in the synthesis of various organic molecules, particularly in the preparation of sulforaphane and related isothiocyanates.

Uses

Used in Pharmaceutical Industry:
4-(Methylthio)butyl azide is used as a synthetic intermediate for the preparation of sulforaphane and related isothiocyanates. These compounds have been found to possess potential health benefits, including antioxidant, anti-inflammatory, and anti-cancer properties. The synthesis of these bioactive molecules is crucial for the development of new drugs and therapies in the pharmaceutical industry.
Used in Chemical Research:
4-(Methylthio)butyl azide is also used as a reagent in chemical research, particularly in the field of organic chemistry. Its unique reactivity and functional group make it a valuable tool for the synthesis of various organic compounds, including those with potential applications in materials science, pharmaceuticals, and other industries.

InChI:InChI=1/C5H12N3S/c1-9-5-3-2-4-7-8-6/h6H,2-5H2,1H3/q+1

Upstream product

• 389131-94-6 toluenesulfonic acid 3-azidobutyl ester 
• 5188-07-8 sodium thiomethoxide 
• 20582-85-8 4-(methylthio)-1-butanol 
• 142415-42-7 methyltetrahydrothiophene triflate 

Downstream Products

• 55021-77-7 4-(methylthio)-1-butylamine 
• 4478-93-7 D,L-sulforaphane 

Relevant articles and documents

Novel broccoli sulforaphane-based analogues inhibit the progression of pancreatic cancer without side effects

The naturally occurring isothiocyanate sulforaphane, found in Brassicaceae vegetables, is promising in cancer treatment, e.g., by the normalization of enhanced levels of NF-κB-signaling in tumor stem cells. We chemically synthesized seven sulforaphane ana

Chemical synthesis method for sulforaphane

The invention discloses a chemical synthesis method for sulforaphane. The method is characterized by including the steps of: (a) taking sodium iodide as the catalyst, reacting 4-chloro-1-butanol with sodium methyl mercaptide to obtain 4-methylthio-1-butanol; (b) in the presence of alkali, reacting 4-methylthio-1-butanol with methylsufonyl chloride to obtain 4-methylthio-1-butylmethysulfonate; (c) reacting4-methylthio-1-butylmethysulfonate with sodium azide in the presence of a phase transfer catalyst to obtain 1-azido-4-methylthiobutane; (d) reacting 1-azido-4-methylthiobutane with triphenylphosphine, and then carrying out reaction with carbon disulfide under a room temperature condition to obtain 1-isothiocyano-4-methylthiobutane; and (e) oxidizing1-isothiocyano-4-methylthiobutane with m-CPBA under a low temperature condition to obtain sulforaphane. The method provided by the invention has the advantages of simple technological process, easy treatment and high total yield (75%), and can achieve effective large-scale production of sulforaphane.

A new and effective approach to the synthesis of sulforaphane

Background: Sulforaphane [1-isothiocyanato-(4-methylsulfinyl)butane] identified from Brassicaceae appears to possess health benefits such as activities against breast, skin and prostate cancer and diabetes. In vitro and vivo studies provide evidence that it can provide protection at every stage of cancer progression. Sulforaphane was firstly synthesized by Von Schmidt and P.Karrer in 1948 via phthalimide route but after Zhang and co-worker reported its bioactivity in 1992, the chemical synthesis of sulforaphane by alternate route has attracted several research groups in the past 20 years. Methods: The synthesis started with the preparation of S-methylthiolanium tetrafluoroborate by sonication of thiolane (1) with methyl iodide followed by anionic metathesis with NaBF4 in n-butanol to give thiolanium tetrafluorborate (2). The ring opening of 2 by SN2 is conducted in 16 hours at 60 °C (as indicated by TLC) to obtain 1-azido-(4-methylsulfinyl)butane (3). Conversion 3 into Erucin (4) was successfully obtained by Staudinger reaction, followed by oxidation of 4 in transition metal-free condition (H2O2/glacial acetic acid) to give sulforaphane in racemic form. Results: Sulforaphane was obtained with 41% yield overall via only four steps with high purity without column chromatography. The approach not only opened up a new synthetic pathway to this naturally occurring isothiocyanate and its analogues, but also suggested a possible solution for converting by-products in petroleum refining processes into useful compounds. Conclusion: Sulforaphane was successfully synthesized from thiolane, a waste product in petroleum processing in a simpler and more efficient fashion, eco-friendy approach. All products were obtained in high yield and high purity. In comparison with previously reported strategies, this new approach is believed to be the shortest and the most efficient synthetic route to date.