5810-96-8

Basic information

• Product Name: 1H-benzo[f]indole-2,3-dione
• Synonyms: Benz[f]isatin;1H-Benz[f]indole-2,3-dione
• CAS NO: 5810-96-8
• Molecular Formula: C₁₂H₇NO₂
• Molecular Weight: 197.1895
• Mol File: 5810-96-8.mol
• Article Data: 4

Chemical Properties

• Density: 1.391g/cm³
• Refractive Index: 1.708
• PKA: 9.33±0.20(Predicted)
• CAS DataBase Reference: 1H-benzo[f]indole-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-benzo[f]indole-2,3-dione(5810-96-8)
• EPA Substance Registry System: 1H-benzo[f]indole-2,3-dione(5810-96-8)

Safety Data

• Hazardous Substances Data: 5810-96-8(Hazardous Substances Data)

Usage

Appearance

Yellow to greenish-brown crystalline solid

Solubility

Sparingly soluble in water

Synonyms

Isatin

Category

Chemical compound

Structure

Benzo[f]indole-2,3-dione

Applications

Organic synthesis, pharmaceuticals, agrochemicals, and material science

Biological activities

Antiviral, antimicrobial, antifungal, anticancer, and anti-inflammatory properties

Role

Versatile building block and precursor for the synthesis of various biologically active compounds

Importance

Valuable target for drug discovery and development

Upstream product

• 875849-93-7 2-(4-dimethylamino-phenylimino)-1,2-dihydro-benz[f]indol-3-one 
• 75753-30-9 trans-2,3,2',3'-benzindigo 
• 5580-64-3 N-(α-Oximino-acetyl)-β-naphthylamin 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 67-64-1 acetone 
• 91-59-8 naphthalen-2-ylamine 
• 73058-82-9 3-acetoxy-1-acetyl-1H-benz[f]indole 
• 873993-80-7 1-acetylbenz[5,6]isatin 2-oxime 

Downstream Products

• 875849-70-0 2-phenyl-benzo[g]quinoline-4-carboxylic acid 
• 5959-52-4 2-Amino-3-naphthoic acid 
• 129833-47-2 3-(2-Carboxymethyl-phenoxy)-naphthalene-2-carboxylic acid 
• 257-89-6 benz[b]acridine 

Relevant articles and documents

Synthesis of benzo-annulated tryptanthrins and their biological properties

A series of benzo-annulated derivatives of tryptanthrin were prepared and their optical and redox properties were studied. Tryptanthrin and its benzo-annulated derivatives showed selective inhibitory activity on topo I with an increase of activity on topo II by benzo-annulation on quinazolin-4(3H)-one moiety. Although the benzo-annulation on quinazolin-4(3H)-one ring did not affect significantly on the inhibitory activities against topo I and II, the benzoannulation on indolin-3-one ring affected the inhibitory activity very much especially by linear annulation. Cytotoxicities were not significantly changed upon benzoannulation, which were not directly related either to the inhibitory activities against topo I and II or to the reduction potentials.

3-SUBSTITUTED OXINDOLE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS

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