58138-79-7

Basic information

• Product Name: 2,6-DIIODOPYRAZINE
• Synonyms: 2,6-DIIODOPYRAZINE;2,6-Diiodopyrizine
• CAS NO: 58138-79-7
• Molecular Formula: C4H2I2N2
• Molecular Weight: 331.88
• Mol File: 58138-79-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 329.733 °C at 760 mmHg
• Flash Point: 153.217 °C
• Appearance: /
• Density: 2.765 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.737
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -2.62±0.10(Predicted)
• CAS DataBase Reference: 2,6-DIIODOPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIIODOPYRAZINE(58138-79-7)
• EPA Substance Registry System: 2,6-DIIODOPYRAZINE(58138-79-7)

Safety Data

• Hazardous Substances Data: 58138-79-7(Hazardous Substances Data)

Usage

General Description

2,6-DIIODOPYRAZINE is a chemical compound with the molecular formula C4H2I2N2. It is a yellow to brown solid and is mainly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2,6-DIIODOPYRAZINE is known for its strong odor and is considered to be a potential respiratory irritant. It is also used as a reagent in organic synthesis, specifically as a building block in the production of heterocyclic compounds. Additionally, 2,6-DIIODOPYRAZINE has been studied for its potential use in the development of new materials, such as conducting polymers and electronic devices. However, due to its toxic and potentially harmful properties, it is important to handle this chemical with caution and in accordance with safety regulations.

InChI:InChI=1/C4H2I2N2/c5-3-1-7-2-4(6)8-3/h1-2H

Upstream product

• 4774-14-5 2,6-dichloropyrazine 

Downstream Products

• 58139-03-0 2-iodo-6-methoxypyrazine 
• 125060-66-4 2-iodo-6-(dimethylamino)pyrazine 
• 125060-75-5 2-iodo-6-allyloxypyrazine 
• 1009378-29-3 2-(6-iodo-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid benzylamide 

Relevant articles and documents

Discovery and structure-activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2

We report the discovery and structure-activity relationship of 2,6-disubstituted pyrazines, which are potent and selective CK2 inhibitors. Lead compound 1 was identified, and derivatives were prepared to develop potent inhibitory activity. As a result, we obtained compound 7, which was the smallest unit that retained potency. Then, introducing an aminoalkyl group at the 6-position of the indazole ring resulted in improved efficacy in both enzymatic and cell-based CK2 inhibition assays. Moreover, compound 13 showed selectivity against other kinases and in vivo efficacy in a rat nephritis model. These results show that 2,6-disubstituted pyrazines have potential as therapeutic agents for nephritis.

tele-Substitution Reactions in the Synthesis of a Promising Class of 1,2,4-Triazolo[4,3- a]pyrazine-Based Antimalarials

We have discovered and studied a tele-substitution reaction in a biologically important heterocyclic ring system. Conditions that favor the tele-substitution pathway were identified: the use of increased equivalents of the nucleophile or decreased equivalents of base or the use of softer nucleophiles, less polar solvents, and larger halogens on the electrophile. Using results from X-ray crystallographic and isotope labeling experiments, a mechanism for this unusual transformation is proposed. We focused on this triazolopyrazine as it is the core structure of the in vivo active antiplasmodium compounds of Series 4 of the Open Source Malaria consortium.

TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, co