58456-26-1

Basic information

• Product Name: 3-Oxazolidinecarboxylic acid, 4-(3-chloro-3-oxopropyl)-5-oxo-, phenylmethyl ester, (S)-
• Synonyms: (S)-3-(benzyloxycarbonyl)-5-oxo-4-oxazolidinepropionyl chloride;(4S)-3-(benzyloxycarbonyl)-4-(3-chloro-3-oxopropyl)-1,3-oxazolidin-5-one;(4S)-4-[2-(Chloroformyl)ethyl]-3-[(phenylmethoxy)carbonyl]oxazolidin-5-one;3-[(4S)-3-benzyloxycarbonyl-5-oxo-1,3-oxazolidin-4-yl]propionyl chloride;(S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]-propanoyl chloride;(S)-3-(benzyloxycarbonyl)-5-oxo-4-oxazolidinepropanoyl chloride
• CAS NO: 58456-26-1
• Molecular Formula: C14H14ClNO5
• Molecular Weight: 311.722
• Mol File: 58456-26-1.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 3-Oxazolidinecarboxylic acid, 4-(3-chloro-3-oxopropyl)-5-oxo-, phenylmethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxazolidinecarboxylic acid, 4-(3-chloro-3-oxopropyl)-5-oxo-, phenylmethyl ester, (S)-(58456-26-1)
• EPA Substance Registry System: 3-Oxazolidinecarboxylic acid, 4-(3-chloro-3-oxopropyl)-5-oxo-, phenylmethyl ester, (S)-(58456-26-1)

Safety Data

• Hazardous Substances Data: 58456-26-1(Hazardous Substances Data)

Upstream product

• 23632-67-9 (S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acid 
• 1155-62-0 N-benzyloxycarbonyl-L-glutamic acid 
• 56-86-0 L-glutamic acid 

Downstream Products

• 58456-27-2 (S)-3-(benzyloxycarbonyl)-4-(4-diazo-3-oxobutyl)-5-oxazolidinone 
• 89969-26-6 (S)-3-(3-benzyloxycarbonyl-5-oxo-1,3-oxazolidin-4-yl)propionaldehyde 
• 118762-77-9 (4S)-N-benzyloxycarbonyl-4-(2-iodoethyl)oxazolidin-5-one 
• 489469-31-0 (4S)-3-(benzyloxycarbonyl)-4-(3-deuterioformylethyl)-1,3-oxazolidin-5-one 
• 848215-17-8 (S)-5-Oxo-4-[2-(2,3,4-trifluoro-phenylcarbamoyl)-ethyl]-oxazolidine-3-carboxylic acid benzyl ester 
• 848215-09-8 (S)-4-[2-(4-Chloro-phenylcarbamoyl)-ethyl]-5-oxo-oxazolidine-3-carboxylic acid benzyl ester 
• 848215-21-4 (S)-4-[2-(4-Methoxy-phenylcarbamoyl)-ethyl]-5-oxo-oxazolidine-3-carboxylic acid benzyl ester 
• 848215-11-2 (S)-4-[2-(2,3-Dichloro-phenylcarbamoyl)-ethyl]-5-oxo-oxazolidine-3-carboxylic acid benzyl ester 
• 848215-13-4 (S)-4-[2-(4-Nitro-phenylcarbamoyl)-ethyl]-5-oxo-oxazolidine-3-carboxylic acid benzyl ester 
• 848215-23-6 (S)-4-[2-(2,4-Dimethyl-phenylcarbamoyl)-ethyl]-5-oxo-oxazolidine-3-carboxylic acid benzyl ester 
• 176847-64-6 (4S)-N-benzyloxycarbonyl-4-[2-[N-2',3'-O,O-(1-methylethylidene)adenosyl-N-methyl]aminoethyl]oxazolidin-5-one 
• 126046-27-3 (2S)-5-oxo-2-[N-(benzyloxycarbonyl)-amino]hexanoic acid methyl ester 
• 126046-26-2 Methyl (S)-3-benzyloxycarbonyl-γ,5-dioxo-4-oxazolidinehexanoate 
• 148315-53-1 bis-{3-[(4S)-3-benzyloxycarbonyl-5-oxo-1,3-oxazolidin-4-yl]propionyl}peroxide 

Relevant articles and documents

Constrained peptidomimetics reveal detailed geometric requirements of covalent prolyl oligopeptidase inhibitors

Prolyl oligopeptidases cleave peptides on the carboxy side of internal proline residues and their inhibition has potential in the treatment of human brain disorders. Using our docking program FITTED, we have designed a series of constrained covalent inhibitors, built from a series of bicyclic scaffolds, to study the optimal shape required for these small molecules. These structures bear nitrile functional groups that we predicted to covalently bind to the catalytic serine of the enzyme. Synthesis and biological assays using human brain-derived astrocytic cells and endothelial cells and human fibroblasts revealed that these compounds act as selective inhibitors of prolyl oligopeptidase activity compared to prolyl-dipeptidyl-aminopeptidase activity, are able to penetrate the cells and inhibit intracellular activities in intact living cells. This integrated computational and experimental study shed light on the binding mode of inhibitors in the enzyme active site and will guide the design of future drug-like molecules.

Nγ-Aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site

Analogues of l-glutamine were designed and synthesized to test a hydrogen-bond hypothesis between ligand and neutral amino acid transporter ASCT2. The key design feature contains a substituted phenyl ring on the amide nitrogen that contains electron withdrawing and electron donating groups that alter the pKa of the amide NH. Through this study a preliminary binding site map has been developed, and a potent commercially available competitive inhibitor of the ASCT2 transporter has been identified.

Biosynthesis of 4-methylproline in cyanobacteria: Cloning of nosE and nosF genes and biochemical characterization of the encoded dehydrogenase and reductase activities

The biosynthesis of the unusual amino acid 4-methylproline in the Nostoc genus of cyanobacteria was investigated on the genetic and enzymatic level. Two genes involved in the biosynthesis were cloned and the corresponding enzymes, a zinc-dependent long-chain dehydrogenase and a Δ1-pyrroline-5-carboxylic acid (P5C) reductase homologue, were overexpressed in Escherichia coli and biochemically characterized. Putative substrates were synthesized to test enzyme substrate specificities, and deuterium labeling studies were carried out to reveal the stereospecificities of the enzymatic reactions with respect to the substrates as well as to the coenzymes.