58484-95-0

Basic information

• Product Name: 1-methyl-2-ohenyl-1H-phenanthro<9,10-d>imidazole
• Synonyms: 1-methyl-2-ohenyl-1H-phenanthro<9,10-d>imidazole
• CAS NO: 58484-95-0
• Molecular Weight: 308.382
• Mol File: 58484-95-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-methyl-2-ohenyl-1H-phenanthro<9,10-d>imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-ohenyl-1H-phenanthro<9,10-d>imidazole(58484-95-0)
• EPA Substance Registry System: 1-methyl-2-ohenyl-1H-phenanthro<9,10-d>imidazole(58484-95-0)

Safety Data

• Hazardous Substances Data: 58484-95-0(Hazardous Substances Data)

Upstream product

• 6931-31-3 2-phenyl-9,10-phenanthroimidazole 
• 77-78-1 dimethyl sulfate 
• 119-61-9 benzophenone 
• 22397-44-0 1-methyl-2,4,5-triphenyl-1H-imidazole 
• 611-97-2 bis(p-methylphenyl)-methanone 
• 134-84-9 4-Methylbenzophenone 
• 133406-40-3 2-methyl-3,5,6-triphenyl-2,5-dihydro-1,2,4-triazinium chloride 
• 573-34-2 2,4,5-triphenyloxazole 
• 24108-44-9 3,5,6-triphenyl-[1,2,4]triazine 
• 81933-67-7 4-methyl-3,5,6-triphenyl-4,5-dihydro-1,2,4-triazine 
• 81933-66-6 2-methyl-3,5,6-triphenyl-2,5-dihydro-1,2,4-triazine 
• 37469-28-6 3,5,6-triphenyl-2⁽⁴⁾,5-dihydro-1,2,4-triazine 
• 133406-37-8 3,5,6-triphenyl-2⁽⁴⁾,5-dihydro-triazinium chloride 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d] imidazoles and imidazo[4,5-f] [1,10]phenanthrolines

The imidazole ring is widespread in biologically active compounds, and hence imidazole-containing scaffolds are useful starting points for drug discovery programmes. We report the synthesis of a series of novel imidazole-containing compounds fused with either phenanthrene or phenanthroline, which show enhanced growth inhibitory potency against human colon, breast and melanoma cancer cell lines, as well as evidence of inhibition of the molecular chaperone heat shock protein 70 (Hsp70) pathway in cells, as shown by depletion of downstream oncogenic client proteins of the Hsp90 chaperone pathway, and induction of apoptosis.

Photochemistry of N-heterocycles. 7: Light induced reductive ring contractions of sixmembered cyclic iminium ions

Photochemically induced reductive ring contractions, previously observed for 2,5-dihydro-1,2,4-triazines, have also been verified for 1,4-dihydropyrimidines 2a,b, the dihydro-1,2,4,5-tetrazine 9, and dihydro-1,3,5-triazines 11a,b giving rise to fivemembered fully unsaturated heterocycles (pyrroles 4a,b, imidazoles 13a,b, and triazole 10, respectively). The 1,4-dihydropyrazines 15a-j tend to decompose in acidified 2-propanol in the dark, but on irradiation they also undergo reductive ring contraction furnishing solely the 1,2,5-triarylpyrroles 16a-d rather than the (a priori also possible) isomeric 1,3,4-triarylpyrroles 17a-d. In contrast, the 3,6-diphenylpyrid-azine 18 gives the 4-isopropyl-analogue 19 in low yield upon irradiation in hydrogen chloride saturated 2-propanol. Wiley-VCH Verlag GmbH, 2000.

PHOTOCHEMISTRY OF N-HETEROCYCLES. PART 1. SYNTHESIS AND PHOTOCHEMISTRY OF SOME 2(4),5-DIHYDRO-1,2,4-TRIAZINES. X-RAY MOLECULAR STRUCTURE OF 1-(4-METHYL-3,5,6-TRIPHENYL-1,4,5,6-TETRAHYDRO-1,2,4-TRIAZIN-6-YL)ETHANOL

Ethanolic solution of the hydrochlorides of the mostly new 2(4),5-dihydro-1,2,4-triazines (1)-(4) were irradiated with a high-pressure mercury immersion lamp (λ>=300 nm).The salts (1a)-(3a) underwent reductions, ring contractions, and dehydrogenations upo