58596-88-6

Basic information

• Product Name: 2,6-Dichloro-3-methyl-5-nitropyridine
• Synonyms: 2,6-Dichloro-3-methyl-5-nitropyridine;Pyridine, 2,6-dichloro-3-Methyl-5-nitro-
• CAS NO: 58596-88-6
• Molecular Formula: C₆H₄Cl₂N₂O₂
• Molecular Weight: 207.01
• Mol File: 58596-88-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 70-71 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 323.536 °C at 760 mmHg
• Flash Point: 149.47 °C
• Appearance: /
• Density: 1.537
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -5.36±0.10(Predicted)
• CAS DataBase Reference: 2,6-Dichloro-3-methyl-5-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-3-methyl-5-nitropyridine(58596-88-6)
• EPA Substance Registry System: 2,6-Dichloro-3-methyl-5-nitropyridine(58596-88-6)

Safety Data

• Hazardous Substances Data: 58596-88-6(Hazardous Substances Data)

Usage

General Description

2,6-Dichloro-3-methyl-5-nitropyridine is a chemical compound with the molecular formula C6H4Cl2N2O2. It is a yellow solid that is used as an intermediate in the production of pharmaceuticals and agrochemicals. 2,6-Dichloro-3-methyl-5-nitropyridine is also used as a building block in organic synthesis, particularly for the preparation of various heterocyclic compounds. It is important to handle this compound with care as it is classified as hazardous and may cause irritation to the skin, eyes, and respiratory system. Moreover, it is important to use it in a well-ventilated area and use personal protective equipment when working with this chemical.

Upstream product

• 58584-94-4 2,6-dichloro-3-methylpyridine 
• 56961-78-5 2,4-dichloro-5-methylpyridine 
• 1241373-24-9 2-chloro-5-methyl-3-nitropyridine 1-oxide 
• 20173-49-3 2-chloro-5-methylpyridine-N-oxide 
• 91668-83-6 2-Chloro-3-methylpyridine N-oxide 
• 22280-56-4 2-chloro-3-methyl-5-nitropyridine 
• 18368-64-4 2-chloro-5-methylpyridine 
• 18368-76-8 2 chloro-3-methylpyridine 
• 23056-40-8 2-chloro-5-methyl-3-nitro-pyridine 

Downstream Products

• 202217-19-4 6-chloro-5-methyl-3-nitropyridin-2-amine 
• 177278-96-5 6-Chloro-5-methyl-3-nitro-2-(2-oxo-cyclohexyl)-pyridine 
• 1258884-09-1 6-chloro-N-(2-fluoro-4-iodophenyl)-5-methyl-3-nitropyridin-2-amine 

Relevant articles and documents

Sulfide Analogues of Flupirtine and Retigabine with Nanomolar KV7.2/KV7.3 Channel Opening Activity

The potassium channel openers flupirtine and retigabine have proven to be valuable analgesics or antiepileptics. Their recent withdrawal due to occasional hepatotoxicity and tissue discoloration, respectively, leaves a therapeutic niche unfilled. Metabolic oxidation of both drugs gives rise to the formation of electrophilic quinones. These elusive, highly reactive metabolites may induce liver injury in the case of flupirtine and blue tissue discoloration after prolonged intake of retigabine. We examined which structural features can be altered to avoid the detrimental oxidation of the aromatic ring and shift oxidation toward the formation of more benign metabolites. Structure–activity relationship studies were performed to evaluate the KV7.2/3 channel opening activity of 45 derivatives. Sulfide analogues were identified that are devoid of the risk of quinone formation, but possess potent KV7.2/3 opening activity. For example, flupirtine analogue 3-(3,5-difluorophenyl)-N-(6-(isobutylthio)-2-(pyrrolidin-1-yl)pyridin-3-yl)propanamide (48) has 100-fold enhanced activity (EC50=1.4 nm), a vastly improved toxicity/activity ratio, and the same efficacy as retigabine in vitro.

NITROGENATED HETEROCYCLIC COMPOUND

The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE

The present application discloses novel substituted 1,4-oxazepanyl-pyridine derivatives and their use as modulators of the voltage gated KV7 (KCNQ) potassium ion channels. In other aspects the application discloses the use of these compounds, i