586976-83-2Relevant articles and documents
Total synthesis and assignment of the double-bond position and absolute configuration of (-)-pyrinodemin A
Morimoto, Yoshiki,Kitao, Satoru,Okita, Tatsuya,Shoji, Takamasa
, p. 2611 - 2614 (2007/10/03)
(Matrix presented) The first asymmetric total synthesis of a structurally novel cis-cyclopent[c]isoxazolidine alkaloid, (-)-pyrinodemin A (3), which exhibits potent cytotoxicity, has been accomplished through a highly diastereoselective intramolecular nitrone - olefin cycloaddition reaction as the key step. Thus, it has been found that the hitherto unknown absolute configuration of pyrinodemin A is as indicated in the structural formula 3.
