587-47-3

Basic information

• Product Name: Ethyl2-(3-fluorophenyl)acetate
• Synonyms: Ethyl2-(3-fluorophenyl)acetate
• CAS NO: 587-47-3
• Molecular Formula: C₁₀H₁₁FO₂
• Molecular Weight: 182.193
• Mol File: 587-47-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 223.97°C at 760 mmHg
• Flash Point: 86.882°C
• Appearance: /
• Density: 1.118g/cm³
• Vapor Pressure: 0.094mmHg at 25°C
• Refractive Index: 1.487
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Ethyl2-(3-fluorophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl2-(3-fluorophenyl)acetate(587-47-3)
• EPA Substance Registry System: Ethyl2-(3-fluorophenyl)acetate(587-47-3)

Safety Data

• Hazardous Substances Data: 587-47-3(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(3-fluorophenyl)acetate is a chemical compound with the molecular formula C10H11FO2. It is a colorless liquid with a fruity odor, commonly used as a flavor and fragrance ingredient in various consumer products. This chemical is synthesized through the esterification of 3-fluorophenylacetic acid with ethanol. It is also used in the pharmaceutical industry for the production of various drugs and medications. Ethyl 2-(3-fluorophenyl)acetate is considered to be a relatively stable and non-hazardous compound, with low flammability and low toxicity. However, it is important to handle and store this chemical with care to prevent any potential risks or hazards.

InChI:InChI=1/C10H11FO2/c1-2-13-10(12)7-8-4-3-5-9(11)6-8/h3-6H,2,7H2,1H3

Upstream product

• 64-17-5 ethanol 
• 331-25-9 (3-fluorophenyl)acetic acid 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 370-45-6 2-(3-fluorophenyl)acetamide 
• 6048-06-2 ethyl-p-chlorocinnamate 
• 20511-20-0 ethyl p-methylcinnamate 
• 101-97-3 Ethyl 2-phenylethanoate 
• 501-00-8 3-fluorophenylacetonitrile 

Downstream Products

• 457-20-5 (3-fluoro-phenyl)-acetic acid-(2-hydroxy-ethylamide) 
• 86215-15-8 1-(m-Fluorophenyl)-3-azabicyclo[3.1.0]hexane 
• 66504-03-8 1-(m-fluorophenyl)-1,2-cyclopropanedicarboximide 
• 66504-02-7 (1R,2S)-1-(3-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid 
• 66504-01-6 (1R,2S)-1-(3-Fluoro-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester 
• 65487-30-1 ethyl 2-(3-fluorophenyl)propanoate 
• 62985-34-6 2-(3-fluorophenyl)succinic acid 
• 110193-59-4 ethyl 2-(3-fluorophenyl)-2-oxoacetate 
• 65487-32-3 2-(3-fluorophenyl)propionic acid 

Relevant articles and documents

2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists

A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.

Rapid Assembly of Saturated Nitrogen Heterocycles in One-Pot: Diazo-Heterocycle “Stitching” by N–H Insertion and Cyclization

Methods that provide rapid access to new heterocyclic structures in biologically relevant chemical space provide important opportunities in drug discovery. Here, a strategy is described for the preparation of 2,2-disubstituted azetidines, pyrrolidines, pi

ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF

The present invention relates to alkaloid aminoester derivatives acting as muscarinic receptor antagonists, to methods of preparing such derivatives, to compositions comprising them and therapeutic use thereof.