65487-32-3

Basic information

• Product Name: 2-(3-fluorophenyl)propionic acid
• Synonyms: 2-(3-fluorophenyl)propionic acid
• CAS NO: 65487-32-3
• Molecular Weight: 168.168
• Mol File: 65487-32-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(3-fluorophenyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-fluorophenyl)propionic acid(65487-32-3)
• EPA Substance Registry System: 2-(3-fluorophenyl)propionic acid(65487-32-3)

Safety Data

• Hazardous Substances Data: 65487-32-3(Hazardous Substances Data)

Usage

Non-steroidal anti-inflammatory drug (NSAID)

It is a medication used to reduce pain and inflammation, commonly prescribed for conditions like arthritis, menstrual cramps, and other acute or chronic pain.

Inhibition of prostaglandin production

The compound works by inhibiting the production of prostaglandins, which are chemicals in the body responsible for causing inflammation and pain.

Fluorophenyl group

The presence of a 3-fluorophenyl group in the molecule contributes to its anti-inflammatory properties and helps in the inhibition of prostaglandin production.

Administration

2-(3-fluorophenyl)propionic acid is typically administered orally in the form of tablets or capsules, making it a convenient and accessible treatment option for patients.

Side effects

As with other NSAIDs, 2-(3-fluorophenyl)propionic acid may cause side effects such as gastrointestinal issues, increased risk of bleeding, and kidney problems. It is essential to consult a healthcare professional before using this medication.

Drug interactions

Patients using other medications, especially other NSAIDs, blood thinners, or corticosteroids, should inform their healthcare provider before starting treatment with 2-(3-fluorophenyl)propionic acid to avoid potential drug interactions and complications.

Upstream product

• 331-25-9 (3-fluorophenyl)acetic acid 
• 74-88-4 methyl iodide 
• 65487-30-1 ethyl 2-(3-fluorophenyl)propanoate 
• 587-47-3 3-fluorophenylacetic acid ethyl ester 
• 124-38-9 carbon dioxide 
• 350-51-6 3-fluorostyrene 
• 1073-06-9 3-fluorobromobenzene 
• 56985-74-1 2-bromopropionic acid sodium salt 
• 64-18-6 formic acid 

Relevant articles and documents

2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists

A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.

Flurbiprofen synthesis method

The invention relates to a flurbiprofen synthesis method and belongs to the technical field of pharmaceutical synthesis. According to the flurbiprofen synthesis method, Suzuki coupling reaction is utilized, the flurbiprofen can be obtained from 2-(3-fluoro-4-bromophenyl) propionic acid and phenyl boron reagent in organic solvent in the alkali condition through palladium catalytic Suzuki coupling reaction; the mole ratio between the 2-(3-fluoro-4-bromophenyl) propionic acid and the phenyl boron reagent is 1: (0.9 to 1.1). The synthesis method is simple, and the obtained flurbiprofen is high in yield and high in purity.

GAMMA SECRETASE MODULATORS

The present invention provides compounds that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions conta