58765-12-1

Basic information

• Product Name: Benzoic acid, 2-hydroxy-5-mercapto-
• CAS NO: 58765-12-1
• Molecular Formula: C7H6O3S
• Molecular Weight: 170.189
• Mol File: 58765-12-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-hydroxy-5-mercapto-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-hydroxy-5-mercapto-(58765-12-1)
• EPA Substance Registry System: Benzoic acid, 2-hydroxy-5-mercapto-(58765-12-1)

Safety Data

• Hazardous Substances Data: 58765-12-1(Hazardous Substances Data)

Upstream product

• 2786-00-7 2-methoxy-5-iodobenzoic acid 
• 17243-13-9 5-chlorosulfonyl-2-hydroxybenzoic acid 
• 21222-64-0 2-hydroxy-5-thiocyanato-benzoic acid 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 24619-05-4 bis-(3-carboxy-4-hydroxyphenyl)disulfide 
• 89-57-6 5-Aminosalicylic Acid 

Downstream Products

• 903568-15-0 5-(2-amino-thiazol-5-ylsulfanyl)-2-hydroxy-benzoic acid methyl ester 
• 439574-89-7 {5-[3-(4-acetyl-piperazine-1-carbonyl)-4-hydroxy-phenylsulfanyl]-thiazol-2-yl}-carbamic acid tert-butyl ester 
• 903568-44-5 1-{4-[5-(2-amino-thiazol-5-ylsulfanyl)-2-hydroxy-benzoyl]-piperazin-1-yl}-ethanone 
• 903568-29-6 5-(2-tert-butoxycarbonylamino-thiazol-5-ylsulfanyl)-2-hydroxy-benzoic acid 
• 24619-05-4 bis-(3-carboxy-4-hydroxyphenyl)disulfide 

Relevant articles and documents

Bacterial reduction as means for colonic drug delivery: Can other chemical groups provide an alternative to the azo bond?

We compared the rate of colonic bacterial reduction of disulfide and nitro bonds to that of an azo counterpart. The disulfide and nitro reduction rates are comparable to that of azo having a similar molecular structure. We further explored QSAR of bacterial reduction of different nitro compounds giving a Hammett correlation with ρ = 0.553, R2 = 0.97. We conclude that disulfide and nitro compounds have an unexploited potential for use in prodrugs and drug delivery systems targeted to the colon.

2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS

The invention relates to 2-thio-substituted imidazole derivatives of formula (I), wherein the radicals R1, R2, R3 and m have the meanings as cited in the description. The inventive compounds comprise an immunomodulatory action and/or an action that inhibits the release of cytokines and are thus suited for treating diseases associated with a disorder of the immune system.