58808-61-0

Basic information

• Product Name: Ethanone, 2,2,2-trifluoro-1-(4-nitrophenyl)- (9CI)
• Synonyms: Ethanone, 2,2,2-trifluoro-1-(4-nitrophenyl)- (9CI);2,2,2-trifluoro-1-(4-nitrophenyl)ethanone;Ethanone, 2,2,2-trifluoro-1-(4-nitrophenyl);4'-Nitro-2,2,2-trifluoroacetophenone
• CAS NO: 58808-61-0
• Molecular Formula: C₈H₄F₃NO₃
• Molecular Weight: 219.1174696
• Product Categories: ACETYLHALIDE
• Mol File: 58808-61-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 253.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.468±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethanone, 2,2,2-trifluoro-1-(4-nitrophenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2,2-trifluoro-1-(4-nitrophenyl)- (9CI)(58808-61-0)
• EPA Substance Registry System: Ethanone, 2,2,2-trifluoro-1-(4-nitrophenyl)- (9CI)(58808-61-0)

Safety Data

• Hazardous Substances Data: 58808-61-0(Hazardous Substances Data)

Usage

General Description

Ethanone, 2,2,2-trifluoro-1-(4-nitrophenyl)- (9CI) is a chemical compound that belongs to the family of ketones. It is characterized by the presence of a trifluoromethyl group and a nitrophenyl group attached to the carbonyl carbon atom. Ethanone, 2,2,2-trifluoro-1-(4-nitrophenyl)- (9CI) is used in various chemical and pharmaceutical applications, including as a reagent in organic synthesis and as a building block for the preparation of various pharmaceutical compounds. It is also known for its potential biological and pharmacological activities, making it a subject of research in drug discovery and development. However, it is important to handle and use this compound with caution, as it may pose hazards to human health and the environment.

Upstream product

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Downstream Products

• 97800-77-6 N,N-Dimethylvalin-(p-nitrophenyl)ester 
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Relevant articles and documents

Trifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones

The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials.

Enantioselective Synthesis of Trifluoromethyl α,β-Unsaturated δ-Lactones via Vinylogous Aldol-Lactonization Cascade

The novel vinylogous aldol-lactonization cascade of alkylidene oxindole with trifluoromethyl ketones is presented. The reaction, catalyzed by a bifunctional tertiary amine, provides an efficient application of the vinylogous reactivity of alkylidene oxindoles for the preparation of enantioenriched trifluoromethylated α,β-unsaturated δ-lactones.

Organocatalytic Aerobic Oxidation of α-Fluoroalkyl Alcohols to Fluoroalkyl Ketones at Room Temperature

The organocatalytic aerobic oxidation of electron-deficient α-fluoroalkyl alcohols at room temperature is described. The resulting fluoroalkyl ketones are versatile synthetic intermediates for a variety of fluorine-containing molecules. This otherwise difficult transformation has now been accomplished by the reaction of α-fluoroalkyl alcohols with N-oxyl radicals, catalytically generated from 9-azabicyclo[3.3.1]nonan-3-one N-oxyl/nitrogen oxide (keto-ABNO/NOx) and oxygen in acetic acid (AcOH), affording the corresponding fluoroalkyl ketones in high yield. This operationally simple reaction can be performed under mild conditions, and was applied to a wide range of alcohols (20 examples), thus demonstrating a high functional group tolerance. Moreover, a modified one-pot protocol based on this method was able to convert an aldehyde to a trifluoromethyl ketone on a gram scale.