593283-31-9

Basic information

• Product Name: 4-(4-chloro-phenyl)-6-methyl-5-[5-(3-nitro-phenyl)-4H-[1,2,4]triazol-3-yl]-3,4-dihydro-1H-pyrimidin-2-one
• CAS NO: 593283-31-9
• Molecular Weight: 410.819
• Mol File: 593283-31-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-chloro-phenyl)-6-methyl-5-[5-(3-nitro-phenyl)-4H-[1,2,4]triazol-3-yl]-3,4-dihydro-1H-pyrimidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chloro-phenyl)-6-methyl-5-[5-(3-nitro-phenyl)-4H-[1,2,4]triazol-3-yl]-3,4-dihydro-1H-pyrimidin-2-one(593283-31-9)
• EPA Substance Registry System: 4-(4-chloro-phenyl)-6-methyl-5-[5-(3-nitro-phenyl)-4H-[1,2,4]triazol-3-yl]-3,4-dihydro-1H-pyrimidin-2-one(593283-31-9)

Safety Data

• Hazardous Substances Data: 593283-31-9(Hazardous Substances Data)

Upstream product

• 5948-71-0 4-(4-chlorophenyl)-5-(ethoxycarbonyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one 
• 104-88-1 4-chlorobenzaldehyde 
• 99-61-6 3-nitro-benzaldehyde 
• 593283-25-1 4-(4-chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid hydrazide 

Relevant articles and documents

Synthesis and anti-microbial activity of some pyrimidine derivatives

4-Aryl-5-carboethoxy-6-methyl-1,2,3,4-tetrahydropyrimidin-2-ones have been synthesized from easily available starting materials. The carboethoxy group at the C5-position of the pyrimidine ring is converted to corresponding hydrazide which in turn is condensed with cyclising agents such as aromatic aldehydes, CS2 etc. to give fused heterocycles. The fused heterocycles are then subjected to phenacylation to give N3-phenacylpyrimido-heterocycles in excellent yield. In a slightly modified way, uracil derivatives are condensed with ethyl bromoacetate to give N3-β-ethoxycarbonyl derivatives. The hydrazide derivatives of these N3-β-ethoxycarbonyl derivatives subsequently react with 1,2-diketones to give corresponding pyrimido pyridazine derivatives.