59377-19-4 Usage
Description
4-Phenoxyphenyl isocyanate, also known as 1-isocyanato-4-phenoxybenzene, is an aryl isocyanate characterized by its clear colorless to slightly yellow liquid appearance. It is a chemical compound with a unique structure that allows it to be utilized in various applications, particularly in the synthesis of different organic compounds.
Uses
Used in Pharmaceutical Industry:
4-Phenoxyphenyl isocyanate is used as a reagent for the preparation of piperazinylquinazoline ureas. It facilitates the condensation of piperazinylquinazoline with aryl isocyanates, which are essential in the development of new pharmaceutical compounds.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-Phenoxyphenyl isocyanate is employed for the synthesis and evaluation of urea-based indazoles. These compounds have potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
The enthalpy of vaporization at the boiling point of 4-Phenoxyphenyl isocyanate has been reported, indicating its importance in understanding the compound's physical properties and potential applications in various chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 59377-19-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,3,7 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 59377-19:
(7*5)+(6*9)+(5*3)+(4*7)+(3*7)+(2*1)+(1*9)=164
164 % 10 = 4
So 59377-19-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H9NO2/c15-10-14-11-6-8-13(9-7-11)16-12-4-2-1-3-5-12/h1-9H
59377-19-4Relevant articles and documents
Electrochemically Enabled Intramolecular Aminooxygenation of Alkynes via Amidyl Radical Cyclization
Hou, Zhong-Wei,Xu, Hai-Chao
supporting information, p. 394 - 398 (2020/03/04)
An electrochemical synthesis of oxazol-2-ones and imidazol-2-ones has been developed via 5-exo-dig cyclization of propargylic carbamates- and ureas-derived amidyl radicals. The electrosynthesis relies on the dual function of 2,2,6,6-tetramethylpiperidin- 1-yl)oxyl (TEMPO) as a redox mediator for amidyl radical formation and an oxygen atom donor. The reactions are conducted under mild conditions using a simple setup and provide convenient access to functionalized oxazol-2-ones and imidazol-2-ones from readily available materials.
Oxime Carbamate-Discovery of a series of novel FAAH inhibitors
Sit,Conway, Charles M.,Xie, Kai,Bertekap, Robert,Bourin, Clotilde,Burris, Kevin D.
supporting information; experimental part, p. 1272 - 1277 (2010/06/17)
A series of novel oxime carbamates have been identified as potent inhibitors of the key regulatory enzyme of the endocannabinoid signaling system, fatty acid amide hydrolase (FAAH). In this Letter, the rationale behind the discovery and the biological evaluations of this novel class of FAAH inhibitors are presented. Both in vitro and in vivo results of selected targets are discussed, along with inhibition kinetics and molecular modeling studies.1.