59386-47-9Relevant articles and documents
Alkylation of magnesium enamide with alkyl chlorides and fluorides
Hatakeyama, Takuji,Ito, Shingo,Nakamura, Masaharu,Nakamura, Eiichi
, p. 14192 - 14193 (2005)
A magnesium enamide derived from N-2-(N′,N′-diethylamino)ethyl imine reacts with a primary and secondary alkyl chloride or a primary alkyl fluoride to give an α-alkylated ketone in good to excellent yield after hydrolysis. The reaction takes place with a high level of inversion of stereochemistry at the electrophilic carbon center and will be useful for production of optically active compounds. Copyright
Enzymatic resolution of bicyclo[n.1.0]alkan-1-ols derivatives: Preparation of optically active α-substituted α-methylcycloalkanones
Morisson,Barnier,Blanco
, p. 7749 - 7764 (2007/10/03)
Optically active α-methyl α-substituted cycloalkanones are prepared by a chemoenzymatic sequence which involves a Lipozyme-catalyzed transesterification of 1-(chloroacetoxy)bicyclo[n.1.0]alkanes and ring opening of these cyclopropanol derivatives.
