59411-02-8

Basic information

• Product Name: (1,2-dimethyl-1H-indol-3-yl)(phenyl)methanone
• CAS NO: 59411-02-8
• Molecular Formula: C₁₇H₁₅NO
• Molecular Weight: 249.3071
• Mol File: 59411-02-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 399.7°C at 760 mmHg
• Flash Point: 195.5°C
• Density: 1.09g/cm³
• Vapor Pressure: 1.34E-06mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: (1,2-dimethyl-1H-indol-3-yl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (1,2-dimethyl-1H-indol-3-yl)(phenyl)methanone(59411-02-8)
• EPA Substance Registry System: (1,2-dimethyl-1H-indol-3-yl)(phenyl)methanone(59411-02-8)

Safety Data

• Hazardous Substances Data: 59411-02-8(Hazardous Substances Data)

Usage

Description

(1,2-dimethyl-1H-indol-3-yl)(phenyl)methanone is a chemical compound with the molecular formula C19H17NO. It is a ketone derivative featuring a phenyl group attached to an indole ring, which endows it with unique structural and potential biological properties.
Used in Organic Synthesis:
(1,2-dimethyl-1H-indol-3-yl)(phenyl)methanone is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for versatile chemical reactions, making it a valuable component in the creation of a wide range of molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (1,2-dimethyl-1H-indol-3-yl)(phenyl)methanone is utilized as a starting material for the development of new drugs. Its potential biological activity and structural features make it a promising candidate for the exploration of novel therapeutic agents.
Used as a Building Block in Chemical Compounds:
Due to its reactive functional groups and structural characteristics, (1,2-dimethyl-1H-indol-3-yl)(phenyl)methanone serves as a building block in the assembly of more complex chemical entities. This application is particularly relevant in the fields of materials science and specialty chemicals where the creation of new materials with specific properties is of interest.

Upstream product

• 875-79-6 1,2-dimethylindole 
• 19798-74-4 2-Ethoxy-2-phenyl-1,3-dioxolane 
• 26211-73-4 (2-methyl-1H-indol-3-yl)phenylmethanone 
• 74-88-4 methyl iodide 
• 1663-61-2 triethoxymethylbenzene 
• 98-88-4 benzoyl chloride 
• 19006-15-6 1,2-dimethyl-3-benzylmethylindole 
• 100-47-0 benzonitrile 
• 1218812-68-0 N-ethyl-N-methyl-2-(phenylethynyl)aniline 
• 611-73-4 Benzoylformic acid 
• 95-20-5 2-methyl-1H-indole 
• 201230-82-2 carbon monoxide 
• 98-80-6 phenylboronic acid 
• 1864-94-4 phenyl formate 

Downstream Products

• 85069-54-1 2-acetoxymethyl-3-benzoyl-1-methylindole 
• 1314146-58-1 (2-(2-hydroxy-4-phenylbut-3-ynyl)-1-methyl-1H-indol-3-yl)(phenyl)methanone 
• 1314146-23-0 9-methyl-4-phenyl-9H-carbazole 
• 1314146-74-1 1-(3-benzoyl-1-methyl-1H-indol-2-yl)-4-phenylbut-3-yn-2-one 
• 1314146-82-1 1-(3-benzoyl-1-methyl-1H-indol-2-yl)dec-3-yn-2-one 
• 1314146-33-2 9-methyl-4-phenyl-9H-carbazol-2-ol 
• 1314146-43-4 (4-hexyl-2-hydroxy-9-methyl-9H-carbazol-3-yl)(phenyl)methanone 
• 1314146-44-5 (4-hexyl-2-hydroxy-9-methyl-9H-carbazol-1-yl)(phenyl)methanone 
• 1314146-68-3 (2-(2-hydroxydec-3-ynyl)-1-methyl-1H-indol-3-yl)(phenyl)methanone 

Relevant articles and documents

Lithium-Promoted Cycloaddition of Indole-2,3-dienolates and Carbon Disulfide as a One-Pot Route to Thiopyrano[4,3- b]indole-3(5 H)-thiones

A new approach for the annulation of a thiopyrane ring to an indole core under mild conditions was developed. Treating 2-methyl-3-acylindoles with lithium diisopropyl amide leads to the elimination of a proton from the 2-methyl group. The lithium indole-2,3-dienolates obtained were found to react with CS2 to give the corresponding thiopyrano[4,3-b]indole-3(5H)-thiones. The mechanism represents a stepwise addition through ion-pair formation, according to PCM/B3LYP/6-311++G**, PBE1PBE/6-311++G**, and MP2//HF/6-311++G*? quantum chemical calculations. AIM calculations revealed the essential role of the Li atom at all stages of the process.

Synthesis of carbonylated heteroaromatic compounds: Via visible-light-driven intramolecular decarboxylative cyclization of o -alkynylated carboxylic acids

An efficient strategy for the easy access to carbonylated heteroaromatic compounds has been developed via a visible-light-promoted intramolecular decarboxylative cyclization reaction of o-alkynylated carboxylic acids. This method is characterized by its b

Decarboxylative/decarbonylative C3-acylation of indoles: Via photocatalysis: A simple and efficient route to 3-acylindoles

A simple and efficient strategy for the preparation of 3-acylindoles via visible-light promoted C3-acylation of free (NH)- and N-substituted indoles with α-oxocarboxylic acids was developed. The reaction tolerates a wide range of functional groups, and the corresponding 3-acylindoles were obtained in high yields under mild conditions.