875-79-6

Basic information

• Product Name: 1,2-Dimethylindole
• Synonyms: 1,2-DIMETHYLINDOLE;1,2-Dimethyl-1H-indole;Indole, 1,2-dimethyl-;N-Methyl-2-methylindole;Dimethylindole;NSC 62087;1,2-Dimethylindole 99%
• CAS NO: 875-79-6
• Molecular Formula: C₁₀H₁₁N
• Molecular Weight: 145.2
• EINECS: 212-877-9
• Product Categories: Intermediates of Dyes and Pigments;Indole;Indoles;Simple Indoles;Building Blocks;Heterocyclic Building Blocks;Heterocycle-Indole series
• Mol File: 875-79-6.mol
• Article Data: 91

Chemical Properties

• Melting Point: 55-58 °C(lit.)
• Boiling Point: 143 °C / 30mmHg
• Flash Point: >230 °F
• Appearance: /Liquid
• Density: 0.99 g/cm³
• Vapor Pressure: 0.0198mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Stability: Stable, but light sensitive. Incompatible with strong oxidizing agents.
• CAS DataBase Reference: 1,2-Dimethylindole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Dimethylindole(875-79-6)
• EPA Substance Registry System: 1,2-Dimethylindole(875-79-6)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 875-79-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 875-79-6 differently. You can refer to the following data:
1. Building block for preparation of 3-functionalized indoles Building block for preparation carbazoles Building block for preparation of cyanoindoles Reactant for preparation of trifluoromethylindoles Reactant for preparation of potent antihyperlipidemic agents Building block in iso-Nazarov or Nazarov cyclizations Reactant for preparation of GSK-3 inhibitors Building block for preparation of carboxyindoles Reactant for preparation of plant growth promoters Reactant for preparation of tryptophan derivatives.
2. Building block for preparation of 3-functionalized indolesBuilding block for preparation carbazolesBuilding block for preparation of cyanoindolesReactant for preparation of trifluoromethylindolesReactant for preparation of potent antihyperlipidemic agentsBuilding block in iso-Nazarov or Nazarov cyclizationsReactant for preparation of GSK-3? inhibitorsBuilding block for preparation of carboxyindolesReactant for preparation of plant growth promotersReactant for preparation of tryptophan derivatives

InChI:InChI=1/C10H11N/c1-8-7-9-5-3-4-6-10(9)11(8)2/h3-7H,1-2H3

Upstream product

• 95-20-5 2-methyl-1H-indole 
• 74-88-4 methyl iodide 
• 603-76-9 1-methylindole 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 3741-86-4 acetone methylphenylhydrazone 
• 31399-19-6 1-(ethyl(phenyl)amino)propan-2-one 
• 4348-19-0 N-ethylaniline hydrochloride 
• 69887-86-1 1,2-dimethyl-3-nitro-pyridinium 
• 6407-34-7 methyl-1 ethylideneamine 
• 6628-07-5 N-allyl-N-methylaniline 
• 41652-73-7 N-Methyl-o-(prop-2-enyl)aniline 
• 26216-93-3 1,2-dimethylindoline 
• 78307-58-1 1-(2-Methylamino-phenyl)-propan-2-one 
• 77129-87-4 E-4-(N-methylanilino)-3-pentene-2-one 

Downstream Products

• 108240-32-0 1,2-dimethyl-3-(2-nitro-1-phenyl-ethyl)-indole 
• 33022-90-1 1-(1,2-dimethyl-1H-indol-3-yl)ethanone 
• 101938-54-9 (1,2-dimethyl-indol-3-yl)-glyoxylic acid dimethylamide 
• 38292-40-9 1,2-dimethyl-1H-indole-3-carbaldehyde 
• 117360-16-4 (1,2-dimethyl-indol-3-yl)-[1,4]benzoquinone 
• 62372-19-4 1,2-Dimethyl-4,5,6,7-tetrahydro-indol 
• 87401-40-9 1,2-dimethyl-octahydro-indole 
• 26216-93-3 1,2-dimethylindoline 
• 87401-40-9 (+/-)-1,2ξ-dimethyl-(3ar,7at)-octahydro-indole 
• 73973-00-9 1,2-Dimethyl-3-phthalidyl-indol 
• 59411-02-8 (1,2-dimethyl-1H-indol-3-yl)(phenyl)methanone 
• 150057-24-2 1,2-dihydro-2-phenyl-2-(1,2-dimethylindol-3-yl)-3H-indol-3-one 
• 150057-21-9 1,2-dimethyl-3-(2-phenylindol-3-yl)indole 
• 150057-22-0 2-phenyl-3,3'-di-(1,2-dimethylindol-3-yl)-3H-indole 

Relevant articles and documents

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Asymmetric transfer hydrogenation of heterocycle-containing acetophenone derivatives using N-functionalised [(benzene)Ru(II)(TsDPEN)] complexes

The application of enantiomerically-pure ruthenium(II) catalysts containing N - functionalised TsDPEN ligand to the asymmetric transfer hydrogenation of 15 examples of α-heterocyclic acetophenone derivatives is reported. Products of up to 99% ee were formed.

Preparation method of nitrogen-alkyl (deuterated alkyl) aromatic heterocycle and alkyl (deuterated alkyl) aryl ether compound

The invention provides a method for preparing nitrogen-alkyl(deuterated alkyl)aromatic heterocycle and alkyl(deuterated alkyl)aryl ether compounds. The method adopted in the invention specifically comprises the following steps: firstly, adding an alkoxy base (MOR') or a combination reagent Q (comprising a base M'X, an alcohol C and a molecular sieve E) into a solvent B to be stirred; then, addingan aromatic compound D of nitrogen sulfonyl or oxygen sulfonyl into a mixture; separating and purifying after reaction to obtain nitrogen-alkyl(deuterated alkyl)aromatic heterocycle or alkyl(deuterated alkyl)aryl ether. The method can realize one-step conversion from an electron withdrawing benzenesulfonyl protecting group on a nitrogen or oxygen atom to an electron donating alkyl protecting group, avoids using highly toxic alkyl halide, and has advantages of being efficient, economical, environmentally friendly, mild in condition, good in substrate universality and high in yield; the prepareddeuterated compounds can be widely applied to the fields of pharmaceutical chemistry and organic chemistry synthesis.

Facile C-S Bond Cleavage of Aryl Sulfoxides Promoted by Bronsted Acid

A method for the Bronsted acid promoted desulfination of aryl sulfoxides is presented. In the presence of a thiol, electron-rich sulfoxides undergo C-S bond cleavage to give the corresponding protodesulfinated arenes and disulfides.