59509-33-0

Basic information

• Product Name: 3-[(Phenylacetyl)amino]-2-azetidinone
• Synonyms: 3-[(Phenylacetyl)amino]-2-azetidinone
• CAS NO: 59509-33-0
• Molecular Weight: 204.228
• Mol File: 59509-33-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-[(Phenylacetyl)amino]-2-azetidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(Phenylacetyl)amino]-2-azetidinone(59509-33-0)
• EPA Substance Registry System: 3-[(Phenylacetyl)amino]-2-azetidinone(59509-33-0)

Safety Data

• Hazardous Substances Data: 59509-33-0(Hazardous Substances Data)

Upstream product

• 103-80-0 phenylacetyl chloride 
• 55826-28-3 3-Methyl-2-((2R,3S)-2-methylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-but-2-enoic acid methyl ester 
• 62634-84-8 3-amino-2-oxoazetidine 
• 78625-07-7 1-(1'-methoxycarbonyl-2'-methylprop-1-enyl)-3-phenylacetamidoazetidin-2-one 

Downstream Products

• 59509-37-4 1-(α-benzyloxycarbonyl-4-benzyloxybenzyl)-3-(2-phenylacetamido)-2-azetidinone 
• 59509-46-5 [2-oxo-3-(2-phenyl-acetylamino)-azetidin-1-yl]-phenyl-acetic acid benzyl ester 
• 59509-42-1 1-(α-methoxycarbonyl-4-methylthiobenzyl)-3-phenylacetamido-2-azetidinone 
• 59509-38-5 1-(α-methoxycarbonyl-3-nitrobenzyl)-3-(2-phenylacetamido)-2-azetidinone 
• 80582-10-1 (S)-3-Amino-2-azetidinone 

Relevant articles and documents

Ruthenium Catalyzed Oxidation of 3-Amino-β-Lactams

3-Aminoazetidin-2-ones were converted into the corresponding 4-acetoxy derivatives by treatment with AcOOH and ruthenium on carbon as catalyst.

Preparation of β-lactams and intermediates therefor

Novel process for the preparation of β-lactams of the formulae: STR1 wherein R' represents lower alkyl, aryl or aryl (lower alkyl), R" represents hydrogen or lower alkyl or R' and R" together with the carbon atoms to which they are attached represent lower cycloalkyl, R'" represents lower alkyl or a group --OR, wherein R represents lower alkyl, X1, Y1 and Z1 are hydrogen or selected organic radicals and R1 represents an acyl group; which successively involves reacting an 1,3-dicarbonyl compound of the formula: STR2 with glycine in the presence of a base to form a vinylamino salt of the formula: STR3 wherein M1+ is the cation of the base, activating the carboxyl group of said vinylamino salt with an appropriate activating agent and reacting the activated compound in the presence of a tertiary base with an imino compound of the formula: STR4 to form the corresponding α-vinylamino-β-lactam of formula IV A and if desired, subjecting said β-lactam to mild acid hydrolysis to obtain the corresponding α-amino-β-lactam of formula V A and if desired, acylating said α-amino-β-lactam with an appropriate acylating agent to obtain a corresponding α-acylamino-β-lactam of formula VI A.