80582-10-1 Usage
Description
(S)-3-Amino-2-azetidinone, also known as AAZ, is a chemical compound characterized by a four-membered ring containing an azetidine moiety and an amino group. It serves as a crucial intermediate in the synthesis of various biologically active compounds, such as pharmaceuticals and agrochemicals. AAZ is a versatile building block in organic synthesis, with its derivatives exhibiting a broad spectrum of pharmacological activities, including antibacterial, antifungal, and antiviral properties. Furthermore, (S)-3-Amino-2-azetidinone is being investigated for its potential applications in the treatment of neurological disorders and cancer. It also finds use as a chiral ligand in organic synthesis and as a reagent in the preparation of complex organic molecules.
Uses
Used in Pharmaceutical Industry:
(S)-3-Amino-2-azetidinone is used as an intermediate for the synthesis of various biologically active compounds, contributing to the development of new pharmaceuticals with potential applications in treating a range of diseases.
Used in Agrochemical Industry:
AAZ is utilized as a building block in the creation of agrochemicals, which are essential for enhancing crop protection and increasing agricultural productivity.
Used in Organic Synthesis:
(S)-3-Amino-2-azetidinone is employed as a chiral ligand in organic synthesis, playing a vital role in the development of complex organic molecules with specific stereochemistry.
Used in Antimicrobial Applications:
AAZ and its derivatives are used as antimicrobial agents for their antibacterial, antifungal, and antiviral properties, providing potential solutions for combating various infectious diseases.
Used in Neurological Disorder Treatment:
(S)-3-Amino-2-azetidinone is being studied for its potential use in the treatment of neurological disorders, offering hope for the development of novel therapeutic approaches to manage such conditions.
Used in Cancer Treatment Research:
AAZ is being explored for its potential applications in cancer treatment, with the aim of developing new therapeutic strategies to combat this complex disease.
Check Digit Verification of cas no
The CAS Registry Mumber 80582-10-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,5,8 and 2 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 80582-10:
(7*8)+(6*0)+(5*5)+(4*8)+(3*2)+(2*1)+(1*0)=121
121 % 10 = 1
So 80582-10-1 is a valid CAS Registry Number.
80582-10-1Relevant articles and documents
Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols
Flanagan, Mark E.,Brickner, Steven J.,Lall, Manjinder,Casavant, Jeffrey,Deschenes, Laura,Finegan, Steven M.,George, David M.,Granskog, Karl,Hardink, Joel R.,Huband, Michael D.,Hoang, Thuy,Lamb, Lucinda,Marra, Andrea,Mitton-Fry, Mark,Mueller, John P.,Mullins, Lisa M.,Noe, Mark C.,O'Donnell, John P.,Pattavina, David,Penzien, Joseph B.,Schuff, Brandon P.,Sun, Jianmin,Whipple, David A.,Young, Jennifer,Gootz, Thomas D.
scheme or table, p. 385 - 390 (2011/07/09)
A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along with the synthesis of one such molecule MC-1 (1). Also reported are structure-activity relationships associated with the in vitro and in vivo efficacy of 1 and related analogues in addition to the hydrolytic stability of such compounds and possible implications thereof.
MONOCARBAMS
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Page/Page column 15, (2010/07/04)
The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, Rs, and R6 as defined herein. The invention also relates to pharmaceutical compositions and methods of treating bacterial infections using compounds of formula (I)
3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors
Zhou, Nian E.,Guo, Deqi,Thomas, George,Reddy, Andhe V. N.,Kaleta, Jadwiga,Purisima, Enrico,Menard, Robert,Micetich, Ronald G.,Singh, Rajeshwar
, p. 139 - 141 (2007/10/03)
A new class of inhibitors for cysteine proteases cathepsin B, L, K and S is described. These inhibitors are based on the β-lactam ring designed to interact with the nucleophilic thiol of the cysteine in the active site of cysteine proteases. Some 3-acylamino-azetidin-2-one derivatives showed very potent inhibition activities for cathepsins L, K and S at the nanomolar or subnanomolar IC50 values.
